美國密歇根大學(xué)綜合癌癥中心的科學(xué)家已經(jīng)發(fā)現(xiàn)攻擊乳腺癌干細(xì)胞的潛在新方法,，腫瘤中的少量細(xì)胞促進(jìn)其生長和擴散,。研究者發(fā)現(xiàn)一組來自骨髓的細(xì)胞調(diào)控乳腺癌干細(xì)胞,，這被稱為間充質(zhì)干細(xì)胞。這些細(xì)胞來自于骨髓,，隨之進(jìn)入腫瘤,，并為腫瘤干細(xì)胞的生長及復(fù)制創(chuàng)造一個"空間"。
美國密歇根大學(xué)綜合癌癥中心主任Max S. Wicha教授說,，我們可通過阻斷來自空間的信號攻擊乳腺腫瘤干細(xì)胞,。
Wicha及其同事在2003年首次發(fā)現(xiàn)乳腺腫瘤干細(xì)胞，腫瘤干細(xì)胞被認(rèn)為是抗化療及抗放射治療,，研究人員認(rèn)為這是癌癥在治療后復(fù)發(fā)的原因,。
關(guān)于腫瘤干細(xì)胞"空間"-一種微環(huán)境類型，與腫瘤的生長和轉(zhuǎn)移密切相關(guān),，了解甚少,。研究者觀察骨髓中出現(xiàn)的間充質(zhì)干細(xì)胞，發(fā)現(xiàn)小鼠中的乳腺腫瘤發(fā)出信號,，將來自骨髓的間充質(zhì)干細(xì)胞吸引至腫瘤,，細(xì)胞可在此相互作用，并刺激乳腺腫瘤干細(xì)胞的生長,。
研究人員隨后發(fā)現(xiàn)來自細(xì)胞因子網(wǎng)絡(luò)（影響細(xì)胞如何溝通的一種蛋白質(zhì)）的兩個信號-主要負(fù)責(zé)干細(xì)胞調(diào)控,。這些相同的細(xì)胞因子在炎癥和阻斷它們的藥物方面發(fā)揮作用，并且這些藥物對于治療炎癥性疾病如風(fēng)濕關(guān)節(jié)炎方面已獲批準(zhǔn),。通過阻斷這些細(xì)胞因子信號,，研究人員希望他們能夠成功地針對腫瘤干細(xì)胞群提供更有效的治療乳腺腫瘤的方法。（生物谷Bioon.com）
英文原文鏈接：http://www.sciencedaily.com/releases/2011/01/110118101354.htm
中文譯文來源：http://www.chinastemcell.org/page/zixun_xwdtlist.aspx?infoid=1020
生物谷推薦英文摘要：
Cancer Research, 2011; 71 (2): 614 DOI: 10.1158/0008-5472.CAN-10-0538
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks.
Liu S, Ginestier C, Ou SJ, Clouthier SG, Patel SH, Monville F, Korkaya H, Heath A, Dutcher J, Kleer CG, Jung Y, Dontu G, Taichman R, Wicha MS.
Comprehensive Cancer Center and School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, USA. [email protected]
We have used in vitro and mouse xenograft models to examine the interaction between breast cancer stem cells (CSC) and bone marrow-derived mesenchymal stem cells (MSC). We show that both of these cell populations are organized in a cellular hierarchy in which primitive aldehyde dehydrogenase expressing mesenchymal cells regulate breast CSCs through cytokine loops involving IL6 and CXCL7. In NOD/SCID mice, labeled MSCs introduced into the tibia traffic to sites of growing breast tumor xenografts where they accelerated tumor growth by increasing the breast CSC population. With immunochemistry, we identified MSC-CSC niches in these tumor xenografts as well as in frozen sections from primary human breast cancers. Bone marrow-derived MSCs may accelerate human breast tumor growth by generating cytokine networks that regulate the CSC population.
