微RNA（miRNA）與信使RNA發(fā)生相互作用來(lái)抑制基因表達(dá),。近日,，刊登在國(guó)際著名雜志Nature上的一篇研究報(bào)告指出Argonaute蛋白在細(xì)胞核中的功能。
Amy Pasquinelli及其同事現(xiàn)在報(bào)告,，miRNA還可以其他非編碼RNA為目標(biāo),。在線蟲中，結(jié)合到Argonaute蛋白ALG-1上的成熟的let-7 miRNA在let-7前體的3’端發(fā)生相互作用,，促進(jìn)其處理,，形成一個(gè)正反饋環(huán)。
這一發(fā)現(xiàn)首次為miRNA-loaded的Argonaute蛋白在細(xì)胞核中確定了一個(gè)功能,。（生物谷Bioon.com）
doi:10.1038/nature11134
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Autoregulation of microRNA biogenesis by let-7 and Argonaute
Dimitrios G. Zisoulis Zoya S. Kai Roger K. Chang Amy E. Pasquinelli
MicroRNAs (miRNAs) comprise a large family of small RNA molecules that post-transcriptionally regulate gene expression in many biological pathways1. Most miRNAs are derived from long primary transcripts that undergo processing by Drosha to produce ~65-nucleotide precursors that are then cleaved by Dicer, resulting in the mature 22-nucleotide forms2, 3. Serving…
