據(jù)新華社6月5日?qǐng)?bào)道，一個(gè)意大利研究團(tuán)隊(duì)日前宣布,，他們嘗試在骨髓中部分再造胰腺功能獲得成功，這將有助于糖尿病患者在胰腺切除手術(shù)后提高生活質(zhì)量,、降低并發(fā)癥風(fēng)險(xiǎn),。最新出版的學(xué)術(shù)期刊《糖尿病》刊登了這一發(fā)現(xiàn)。
米蘭圣拉斐爾醫(yī)院的這個(gè)研究團(tuán)隊(duì)修改了針對(duì)1型糖尿病患者的胰島移植程序,。他們從捐贈(zèng)者的胰腺中提取內(nèi)分泌細(xì)胞,，植入患者的盆骨骨髓中，“再造”部分胰腺功能,。目前,，研究團(tuán)隊(duì)已經(jīng)在4位胰腺全部切除的糖尿病患者身上進(jìn)行了臨床試驗(yàn)，經(jīng)過(guò)3年觀察,，植入的內(nèi)分泌組織在患者骨髓中“扎根并工作”,。
通常情況下，部分糖尿病患者胰腺被摘除后,，由于來(lái)自胰腺的胰島素及胰高血糖素等激素分泌被破壞,，致使胰腺在體內(nèi)承擔(dān)的糖代謝調(diào)節(jié)功能缺失，給病人生活帶來(lái)很多不便,。新研究正是致力于改變這種狀況,。
此外，新研究的意義還在于證明了內(nèi)分泌組織等非造血組織也可以在骨髓之類(lèi)的環(huán)境中存活并發(fā)揮功用,，而通常的理解是骨髓里主要存在造血干細(xì)胞,。這可能為再生醫(yī)學(xué)打開(kāi)一扇新的窗戶(hù)。
生物谷推薦的文章內(nèi)容
Diabetes doi: 10.2337/diab.9.6.447
Effects of Insulin on Blood Glucose Entry and Removal Rates in Man
George A. Reichard, A. Gerson Jacobs, Philip Kimbel, Norman J. Hochella, Sidney Weinhouse
By measuring the rate of decline of the specific radioactivity of blood glucose following injection of a single dose of glucose uniformly labeled with carbon-14, one can calculate its rates of entry to and removal from the blood.In applying this procedure in experiments with intact dogs and human subjects results were obtained that indicated that the immediate hypoglycemic action of insulin is due not only to an accelerated removal, but also to a lowered inflow of blood glucose. However, the relative quantitative importance of each of these effects is still uncertain. Inasmuch as the liver is in all likelihood the principal source of the blood glucose, and since this organ has a considerable capacity for binding insulin, it may be anticipated that hepatic effects of insulin might predominate during its slow introduction into the blood, such as would occur when it is physiologically secreted. It has been reported that intraportal injection of insulin is not as effective in lowering blood sugar as peripheral venous injection. Moreover, the oral hypoglycemic agents, whose effects are generally attributed to their ability to stimulate pancreatic insulin secretion, apparently suppress hepatic glucose output but have little effect on peripheral glucose utilization. To gain further information on the possible quantitative importance of an hepatic effect of insulin, a series of experiments was conducted in which a slow, steady introduction of insulin into the bloodstream was established by subcutaneous injection of the hormone.
The results of the earlier studies were extended and confirmed in indicating that a slow, regular entry of insulin into the blood prolongs the hepatic effect and decreases the peripheral action as compared with a single intravenous injection.
