細(xì)胞衰老會(huì)引起衰老相關(guān)性輕度炎癥（senescence-associated para-inflammation）,。這種炎癥反應(yīng)一方面通過(guò)延續(xù)生長(zhǎng)抑制,，清除衰老細(xì)胞保持了正常器官組織的穩(wěn)態(tài)，抑制了癌癥的發(fā)生發(fā)展,；另一方面炎癥反應(yīng)也為癌細(xì)胞帶來(lái)了支持其生長(zhǎng)的巨噬細(xì)胞,，成纖維細(xì)胞并促進(jìn)癌組織中血管的生成。那么什么是這種炎癥反應(yīng)在這兩個(gè)不同角色之間轉(zhuǎn)換的關(guān)鍵呢,？來(lái)自以色列,、德國(guó)、芬蘭,、美國(guó)的研究者在CKIα基因敲除的小鼠腸組織中找到了答案,。在小鼠腸組織中單獨(dú)缺失或降低CKIα表達(dá)量時(shí)，會(huì)引起衰老相關(guān)的輕度炎癥反應(yīng)并且伴隨著大腸癌的生長(zhǎng)停滯,。而當(dāng)同時(shí)缺失p53時(shí),，這個(gè)炎癥反應(yīng)會(huì)失去對(duì)癌細(xì)胞增殖的控制能力，反而會(huì)加快癌細(xì)胞的增殖及侵染,。文章還闡明了炎癥抑制性非固醇類(lèi)抗癌藥物的可能機(jī)制,。（生物谷 Bioon.com）
生物谷推薦的英文內(nèi)容
Cell Cancer Cell Doi: 10.1016/j.ccr.2013.06.005
A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism
Ariel Pribluda, Ela Elyada, Zoltan Wiener, Haya Hamza, Robert E. Goldstein, Moshe Biton, Ido Burstain,Yael Morgenstern, Guy Brachya, Hana Billauer, Sharon Biton, Irit Snir-Alkalay, Domagoj Vucic, Katharina Schlereth,Marco Mernberger, Thorsten Stiewe, Moshe Oren, Kari Alitalo, Eli Pikarsky and Yinon Ben-Neriah
Senescence, perceived as a cancer barrier, is paradoxically associated with inflammation, which promotes tumorigenesis. Here, we characterize a distinct low-grade inflammatory process in stressed epithelium that is related to para-inflammation; this process either represses or promotes tumorigenesis, depending on p53 activity. Csnk1a1 (CKIα) downregulation induces a senescence-associated inflammatory response (SIR) with growth arrest in colorectal tumors, which loses its growth control capacity in the absence of p53 and instead, accelerates growth and invasiveness. Corresponding processes occur in CKIα-deleted intestinal organoids, assuming tumorigenic transformation properties ex vivo, upon p53 loss. Treatment of organoids and mice with anti-inflammatory agents suppresses the SIR and prevents p53-deficient organoid transformation and mouse carcinogenesis. SIR/para-inflammation suppression may therefore constitute a key mechanism in the anticarcinogenic effects of nonsteroidal anti-inflammatory drugs.
