GOA是一個(gè)由EBI開發(fā)的數(shù)據(jù)庫,，其目標(biāo)是提供一個(gè)從基因產(chǎn)物到GO標(biāo)識(shí)的鏈接資源,。我們已經(jīng)很多次介紹過GO了,，簡要來說，GO的目標(biāo)就是產(chǎn)生一個(gè)可以動(dòng)態(tài)控制的詞表來標(biāo)識(shí)基因產(chǎn)物，即使該基因或蛋白在細(xì)胞內(nèi)的作用或功能仍然處于知識(shí)積累階段并且在不斷更新中,。在GOA計(jì)劃中,，該詞表將被應(yīng)用到Swiss-Prot，TrEMBL and Ensemble中的非冗余蛋白數(shù)據(jù)集中,。編者認(rèn)為GOA在功能基因組研究中將發(fā)揮重要作用,，那么我們能利用GOA作哪些工作呢，下面是GOA開發(fā)者舉的一些例子：
access functional information for the human proteome (GOA-Human) or for any protein in EBI's protein databases (GOA-SPTR).
ask questions such as ''find me all proteins involved in apoptosis(GO:0006915) but not involved via death domain receptors (GO:0008625), and then find their coding sequences'.
use GO-Slim to summarize the biological attributes of a proteome, compare proteomes, or find out what proportion of a proteome is involved in eg. 'transport'.
incorporate our manual annotation into your own databases to enhance your dataset, or use it to validate your automated way of deriving information about gene function.
map GO terms to your own datasets; for example, our GO mapping to InterPro entries (InterPro2GO) can be used to annotate mass spectrometry or microarray data.
find the location of human genes mapped to a particular GO term using ensembl GO-View.
你想要詳細(xì)了解GOA計(jì)劃嗎,？那么請(qǐng)?jiān)L問以下鏈接：http://www.ebi.ac.uk/GOA/index.html
