生物谷報道：有絲分裂的機理研究一直是研究的熱點,，這篇報道的最大意義在于采用了熒光探針,，使細胞的有絲分裂過程真實地呈現(xiàn)在大家的面前,，這一技術(shù)給今后的細胞內(nèi)更多活動的可視化研究帶來沖擊,。
Familiarity with the exact timing of cell-cycle events is important for understanding disease mechanisms and for determining the effects of drugs on the cell cycle. In this month's Nature Biotechnology, Joshua Jones and colleagues have engineered a new fluorescent biosensor that enables mitosis to be monitored simultaneously in a large number of cells. A shuttling fluorescent protein allows the time between nuclear-envelope breakdown and reformation to be tracked precisely in up to several hundred cells at once. Conly Rieder and Alexei Mikhailov review the work in an accompanying News and Views article.
article
Probing the precision of the mitotic clock with a live-cell fluorescent biosensor
J. T. JONES et al.
Nature Biotechnology 22, 306; March 2004
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