生物谷報(bào)道：細(xì)胞內(nèi)信號(hào)以往認(rèn)為是單一行為,，其實(shí)從數(shù)學(xué)模型來(lái)看，單一,，線性的信號(hào)模式,，是極其脆弱的，因?yàn)橹灰渲心骋粋€(gè)因子（物質(zhì)）出現(xiàn)問(wèn)題,，表達(dá)多或少了,，都會(huì)導(dǎo)致信號(hào)的失真。實(shí)際上在細(xì)胞內(nèi)的信號(hào)傳遞是高度精密的,，不僅能將不同的信號(hào)傳遞進(jìn)細(xì)胞內(nèi),，而且能精確地傳遞定位和定量信息，從而使細(xì)胞能精確地外界刺激作出特定的反應(yīng),。因此信號(hào)網(wǎng)絡(luò)模型被認(rèn)為是解釋信號(hào)傳遞的可能方式,。但是細(xì)胞信號(hào)間crosstalk可以通過(guò)反饋和負(fù)反饋保證信號(hào)的精確性，那么如何保證信號(hào)的穩(wěn)定性,？北大Chao Tang最新在酵母中研究酵母的細(xì)胞周期信號(hào)中驚奇地發(fā)現(xiàn),，細(xì)胞周期信號(hào)具有超強(qiáng)的穩(wěn)定性，保證酵母能不斷地增殖，并提出了數(shù)學(xué)模型, 這篇文章發(fā)表在最近的PNAS上,。
The interactions between proteins, DNA, and RNA in living cells constitute molecular networks that govern various cellular functions. To investigate the global dynamical properties and stabilities of such networks, we studied the cell-cycle regulatory network of the budding yeast. With the use of a simple dynamical model, it was demonstrated that the cell-cycle network is extremely stable and robust for its function. The biological stationary state, the G1 state, is a global attractor of the dynamics. The biological pathway, the cell-cycle sequence of protein states, is a globally attracting trajectory of the dynamics. These properties are largely preserved with respect to small perturbations to the network. These results suggest that cellular regulatory networks are robustly designed for their functions.
原文閱讀和下載
Fangting Li, Tao Long, Ying Lu, Qi Ouyang, and Chao Tang The yeast cell-cycle network is robustly designed
PNAS 2004 101: 4781-4786; published online before print March 22 2004, 10.1073/pnas.0305937101 [Full Text] [PDF] [Supporting Information]
