生物谷報道：細胞內(nèi)信號以往認為是單一行為,，其實從數(shù)學模型來看,，單一,，線性的信號模式，是極其脆弱的，因為只要其中某一個因子（物質(zhì)）出現(xiàn)問題,，表達多或少了,，都會導致信號的失真。實際上在細胞內(nèi)的信號傳遞是高度精密的,，不僅能將不同的信號傳遞進細胞內(nèi),，而且能精確地傳遞定位和定量信息，從而使細胞能精確地外界刺激作出特定的反應,。因此信號網(wǎng)絡模型被認為是解釋信號傳遞的可能方式,。但是細胞信號間crosstalk可以通過反饋和負反饋保證信號的精確性，那么如何保證信號的穩(wěn)定性,？北大Chao Tang最新在酵母中研究酵母的細胞周期信號中驚奇地發(fā)現(xiàn),，細胞周期信號具有超強的穩(wěn)定性，保證酵母能不斷地增殖,，并提出了數(shù)學模型, 這篇文章發(fā)表在最近的PNAS上,。
The interactions between proteins, DNA, and RNA in living cells constitute molecular networks that govern various cellular functions. To investigate the global dynamical properties and stabilities of such networks, we studied the cell-cycle regulatory network of the budding yeast. With the use of a simple dynamical model, it was demonstrated that the cell-cycle network is extremely stable and robust for its function. The biological stationary state, the G1 state, is a global attractor of the dynamics. The biological pathway, the cell-cycle sequence of protein states, is a globally attracting trajectory of the dynamics. These properties are largely preserved with respect to small perturbations to the network. These results suggest that cellular regulatory networks are robustly designed for their functions.
原文閱讀和下載
Fangting Li, Tao Long, Ying Lu, Qi Ouyang, and Chao Tang The yeast cell-cycle network is robustly designed
PNAS 2004 101: 4781-4786; published online before print March 22 2004, 10.1073/pnas.0305937101 [Full Text] [PDF] [Supporting Information]
