12月15日出版的《國(guó)際癌癥雜志》上德國(guó)研究者的一篇報(bào)道指出,，人類(lèi)惡性黑色素瘤標(biāo)本研究提示最近證實(shí)的基因TANGO有抑制腫瘤的作用,。
據(jù)美國(guó)媒體消息，德國(guó)雷根斯堡大學(xué)的研究者Anja K. Bosserhoff及其同事說(shuō),，她們首次發(fā)現(xiàn)在癌癥中TANGO分子下調(diào)或者丟失,，TANGO的減少與疾病進(jìn)展期相關(guān)。
研究者發(fā)現(xiàn)與正常黑色素細(xì)胞相比,，9種黑色素細(xì)胞中都有TANGO丟失或者下調(diào),。在八個(gè)人類(lèi)腫瘤標(biāo)本中，大多數(shù)也是這樣,，并且TANGO與進(jìn)展期腫瘤相關(guān),。在原發(fā)和轉(zhuǎn)移性黑色素瘤的切片中證實(shí)了這一發(fā)現(xiàn)。
研究者還發(fā)現(xiàn)良性黑色素瘤和不典型痣都有TANGO輕度減少,。然而,，他們注意到這些變化并不明顯，而且有較大變異性,。
黑色素瘤相關(guān)的進(jìn)一步實(shí)驗(yàn)表明TANGO表達(dá)增加會(huì)導(dǎo)致腫瘤侵襲能力和活動(dòng)能力明顯降低,，反之亦然。
Bosserhoff博士說(shuō)：“因此,，TANGO表達(dá)丟失可能是一個(gè)黑色素瘤患者疾病進(jìn)展的預(yù)后標(biāo)志,，可用于腫瘤診斷學(xué)。”
至于TANGO的潛在治療應(yīng)用,，作者總結(jié)說(shuō)：“還需要以后進(jìn)行更多的研究來(lái)評(píng)價(jià),。”
英文原文：
TANGO Inhibits Malignant Melanoma Tumors
NEW YORK (Reuters Health) Dec 15 - Study of human malignant melanoma tumor specimens suggests that the recently identified gene TANGO has a tumor inhibitory role, German researchers report in the December 15th issue of the International Journal of Cancer.
Dr. Anja K. Bosserhoff told Reuters Health that she and her colleague Dr. Stephanie Arndt have documented "for the first time that the molecule TANGO is down-regulated or even lost in cancer and that the process of TANGO reduction correlates with advanced stage of the disease."
The researchers, both from the University of Regensburg, found that compared to normal melanocytes, TANGO was lost or downregulated in 9 melanoma cell lines. This was also true of most of 8 human tumor samples, and was associated with advanced tumor stage. The findings were confirmed in sections of melanoma primary tumors and metastases.
The team also found a small reduction in TANGO in benign and atypical nevi. However, they note that it was "less dramatic" and there was considerable variability.
Further melanoma experiments indicated that an increase in TANGO expression resulted in a significant decrease in invasive potential and motility. The converse was also true.
"Therefore," continued Dr. Bosserhoff, "loss of TANGO expression may be a prognostic marker of progression in melanoma patients, usable in tumor diagnostics."
A potential therapeutic use of TANGO, she concluded, "has to be evaluated in future studies."
