根據(jù)一篇發(fā)表于Journal of the American Chemical Society網(wǎng)絡(luò)版的文章「Aggregation of Rod-Coil Block Copolymers Containing Rigid Polyampholyte Blocks in Aqueous Solution」中，巨分子與接口研究所(Macromolecules and Interfaces Institute)的研究人員S. Richard Turner合成了一種新的帶電,、桿狀共聚物家族,，它的長度只有人類頭發(fā)的直徑，可以帶正電或負(fù)電,，也可以交替地攜帶正電及負(fù)電,。
這種小的桿狀分子可以自行組裝,，而且聚集后的結(jié)構(gòu)在生理食鹽水中相當(dāng)穩(wěn)定。這項研究結(jié)果也將于3月25-29日在芝加哥舉行的,，第233屆美國化學(xué)學(xué)會會議中發(fā)表,。
這項研究的早期結(jié)果建議,，這些帶電的聚合物,，可以經(jīng)由類似DNA等自然聚合物之同電荷間的交互作用而自行聚集。穩(wěn)定的自組結(jié)構(gòu),，將可以應(yīng)用于藥物傳遞和基因傳遞系統(tǒng)中,。這些獨特的共聚物也可以成為研究DNA的教育模型。
(資料來源 : Bio.com)
部分英文原文：
J. Am. Chem. Soc., 129 (13), 3832 -3833, 2007. 10.1021/ja070422+ S0002-7863(07)00422-2
Web Release Date: March 10, 2007 Copyright © 2007 American Chemical Society
Aggregation of Rod-Coil Block Copolymers Containing Rigid Polyampholyte Blocks in Aqueous Solution
Min Mao and S. Richard Turner*
Department of Chemistry, Macromolecules and Interfaces Institute (MII), Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0344
Received January 19, 2007
Abstract:
Rod-coil block copolymers containing rigid polyampholyte blocks were designed and synthesized by RAFT copolymerization. The rigid polyampholyte blocks were formed by hydrolysis of alternating copolymers of N,N,N',N'-tetraethyl-4,4'-diaminostilbene with maleic anhydride, and the flexible coil block consists of poly(oligo(ethylene glycol)methacrylate). The rod-coil block copolymers form polyion complex (PIC) aggregates even when the polyampholyte blocks are charge imbalanced. The aggregates did not dissociate upon the addition of high concentrations of NaCl unlike the dissociation of flexible polyampholytes in NaCl solution. These unique solution properties are induced by like-charge attractions of the rigid polyampholytic alternating copolymer chains.
( 生物谷配圖)
更多生物圖片請進入
