生物谷：一種蛋白通道被假設(shè)為內(nèi)質(zhì)網(wǎng)（ER）的一個(gè)構(gòu)成部分，來(lái)解釋誤折疊蛋白和非包裹病毒能夠通過(guò)ER進(jìn)入細(xì)胞質(zhì)這一事實(shí),。酵母中的Der1蛋白和其他真核細(xì)胞中的Derlins是有可能在這樣的轉(zhuǎn)位通道（dislocon）中發(fā)揮功能的蛋白類(lèi)型的例子,。但Hidde Ploegh在本刊非定期推出的“假設(shè)”（Hypothesis）欄目中撰文提出另一個(gè)機(jī)制，該機(jī)制也許能夠無(wú)需一個(gè)基于蛋白的通道而對(duì)上述事實(shí)做出解釋,。按照這個(gè)機(jī)制,，由類(lèi)脂重排誘發(fā)而打開(kāi)的一個(gè)逃逸門(mén)可讓蛋白和病毒都通過(guò)ER。（生命經(jīng)緯）
原始出處:
Nature 448, 435-438 (26 July 2007) | doi:10.1038/nature06004
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum
Hidde L. Ploegh1
Whitehead Institute, MIT Department of Biology, Cambridge, Massachusetts 02142, USA
Correspondence to: Hidde L. Ploegh1 Correspondence should be addressed to H.L.P. (Email: [email protected]).
Lipids are not encoded by a DNA template and therefore cannot be mutated, knocked out or knocked down. This by no means renders them impotent from a cell biological perspective. Here I propose a model for the involvement of lipid rearrangements in the execution of crucial steps in (glyco)protein quality control.
圖：Biogenesis of lipid droplets and a model for their involvement in escape of macromolecules and viruses from the ER.
