生物谷報(bào)道：蛋白質(zhì)B-crystallin主要存在于眼睛的晶狀體中,，它在多發(fā)性硬化中所發(fā)生的炎癥和損傷的發(fā)展過程中可能是關(guān)鍵的“引爆點(diǎn)”。過去，人們知道它是多發(fā)性硬化患者體內(nèi)一個(gè)主要免疫目標(biāo)?，F(xiàn)在,，用小鼠所做的研究工作表明,，該蛋白在一個(gè)多發(fā)性硬化模型中還扮演一個(gè)保護(hù)角色,。當(dāng)將其注射進(jìn)實(shí)驗(yàn)鼠體內(nèi)時(shí)，它起一種消炎和神經(jīng)保護(hù)因子的作用,，并且還能使癱瘓發(fā)生逆轉(zhuǎn),。該研究成果發(fā)表在最新一期的《自然》雜志上。
原文出處：
Nature Volume 448 Number 7152
Protective and therapeutic role for B-crystallin in autoimmune demyelination p474
Shalina S. Ousman, Beren H. Tomooka, Johannes M. van Noort, Eric F. Wawrousek, Kevin O'Conner, David A. Hafler, Raymond A. Sobel, William H. Robinson & Lawrence Steinman
doi:10.1038/nature05935
First paragraph | Full Text | PDF (1,046K) | Supplementary information
See also: Editor's summary | News and Views by Ransohoff
作者簡介：
Lawrence Steinman
Academic Appointments
Appointment
Organization
ProfessorNeurology & Neurological Sciences
ProfessorPediatrics
Professor (By courtesy)Genetics
Research Interests
Our laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.
Publications
§Dunn SE, Ousman SS, Sobel RA, Zuniga L, Baranzini SE, Youssef S, Crowell A, Loh J, Oksenberg J, Steinman L "Peroxisome proliferator-activated receptor (PPAR){alpha} expression in T cells mediates gender differences in development of T cell-mediated autoimmunity." J Exp Med 2007; More »
§Steinman L, "A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage." Nat Med 2007; 13: 2: 139-45 More »
§Kanter JL, Narayana S, Ho PP, Catz I, Warren KG, Sobel RA, Steinman L, Robinson WH "Lipid microarrays identify key mediators of autoimmune brain inflammation." Nat Med 2006; 12: 1: 138-143 More »
§Dunn SE, Youssef S, Goldstein MJ, Prod'homme T, Weber MS, Zamvil SS, Steinman L "Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin." J Exp Med 2006; 203: 2: 401-12 More »
§Langer-Gould A, Steinman L "What went wrong in the natalizumab trials?" Lancet 2006; 367: 9512: 708-10 More »
