德國(guó)科學(xué)家最新的發(fā)現(xiàn)表明，不久的將來(lái),，使用血液興奮劑EPO(促紅細(xì)胞生長(zhǎng)素)就如同洗發(fā)一樣方便,，當(dāng)然這項(xiàng)技術(shù)也可以應(yīng)用治療重癥貧血病人。該研究的成果發(fā)表于最新一期的FASEB 雜志上,。
每個(gè)人頭部大約有10萬(wàn)個(gè)毛囊,，研究人員發(fā)現(xiàn)毛囊可以成為EPO的生產(chǎn)工廠,。EPO不僅可以促進(jìn)紅細(xì)胞在體內(nèi)的生長(zhǎng)，目前也認(rèn)為是骨髓外組織自我保護(hù)的重要物質(zhì),。毛囊是人體增生最快的組織,，研究發(fā)現(xiàn)，在體外,，缺氧或化學(xué)作用的刺激下,，毛囊促發(fā)EPO和EPO相關(guān)受體明顯增加。此項(xiàng)研究表明,，在外界環(huán)境的刺激下毛囊有可能成為EPO的生產(chǎn)基地,，目前只是基礎(chǔ)研究，但是科學(xué)家認(rèn)為進(jìn)一步的研究也許可以使人類在任何需要的時(shí)刻由毛囊提供EPO,，成為一種有效,、安全、廉價(jià)的EPO的生產(chǎn)方法,，對(duì)運(yùn)動(dòng)員而言,，也許如需使用EPO，改變一下發(fā)型就可以提升體內(nèi)EPO的水平,。
通常,，運(yùn)動(dòng)員使用EPO來(lái)增強(qiáng)血液的供氧能力，希望通過(guò)提高耐力而提高運(yùn)動(dòng)成績(jī),。（中國(guó)經(jīng)營(yíng)報(bào)）
原始出處:
Published as doi: 10.1096/fj.07-8628com.
(The FASEB Journal. 2007;21:3346-3354.)
Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin
Enik Bodó*,1, Arno Kromminga,1, Wolfgang Funk, Magdalena Laugsch, Ute Duske, Wolfgang Jelkmann and Ralf Paus*,2
* Department of Dermatology, University of Lübeck, Lübeck, Germany;
Institute for Immunology, Clinical Pathology, Molecular Medicine, Hamburg, Germany;
Klinik Dr. Kozlowski, Munich, Germany; and
Department of Physiology, University of Lübeck, Lübeck, Germany
2Correspondence: Department of Dermatology, University Hospital Schleswig-Holstein, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany. E-mail: [email protected]
Erythropoietin primarily serves as an essential growth factor for erythrocyte precursor cells. However, there is increasing evidence that erythropoietin (EPO)/EPO receptor (EPO-R) signaling operates as a potential tissue-protective system outside the bone marrow. Arguing that growing hair follicles (HF) are among the most rapidly proliferating tissues, we have here explored whether human HFs are sources of EPO and targets of EPO-R-mediated signaling. Human scalp skin and microdissected HFs were assessed for EPO and EPO-R expression, and the effects of EPO on organ-cultured HFs were assessed in the presence/absence of a classical apoptosis-inducing chemotherapeutic agent. Here, we show that human scalp HFs express EPO on the mRNA and protein level in situ, up-regulate EPO transcription under hypoxic conditions, and express transcripts for EPO-R and the EPO-stimulatory transcriptional cofactor hypoxia-inducible factor-1. Although EPO does not significantly alter human hair growth in vitro, it significantly down-regulates chemotherapy-induced intrafollicular apoptosis and changes the gene expression program of the HFs. The current study points to intriguing targets of EPO beyond the erythropoietic system: human HFs are an extrarenal site of EPO production and an extrahematopoietic site of EPO-R expression. They may recruit EPO/EPO-R signaling e.g., for modulating HF apoptosis under conditions of hypoxia and chemotherapy-induced stress.—Bodó, E., Kromminga, A., Funk, W., Laugsch, M, Duske, U., Jelkmann, W., Paus, R. Human hair follicles are an extrarenal source and a non-hematopoietic target of erythropoietin.
Key Words: anagen hair follicles • tissue protection • hemoglobin alpha-1 • kinesin light chain 3 • aminase oxidase • calmegin • RAS-like family 10
