材料科學(xué)家從自然界中得到提示,，成功地把多巴胺作為有機(jī)和無機(jī)表面的萬能膠,。把兩種材料粘合在一起是一個常見的工程挑戰(zhàn)。雖然科學(xué)家在實(shí)驗(yàn)室制造出各種各樣的膠,，但是大多數(shù)只在有限的條件下能用,。Haeshin Lee和同事從貽貝中得到啟示,，貽貝的膠蛋白質(zhì)能粘到幾乎所有的表面,。他們用一個叫左旋多巴(levodopa)的小分子簡單地模擬具有結(jié)合與粘合性能的貽貝蛋白，左旋多巴是合成多巴胺過程中的一個生物中間體,，多巴胺在大腦調(diào)節(jié)中起作用,。Lee和同事在與酸堿度匹配貽貝的海洋環(huán)境的容器中制造了稀釋的多巴胺溶液,，然后把金屬、塑料,、和陶瓷襯底放到溶液中,。一層薄薄的高分子膠生長到襯底上，這種膠能同樣地粘合到復(fù)雜的和有圖案的表面,。這種材料還有一個好處,，它能經(jīng)受次級反應(yīng)，比如金屬化或自組裝的單層形成,，從而擴(kuò)大了其應(yīng)用范圍,。
原始出處:
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Science 19 October 2007:
Vol. 318. no. 5849, pp. 426 - 430
DOI: 10.1126/science.1147241
Mussel-Inspired Surface Chemistry for Multifunctional Coatings
Haeshin Lee,1 Shara M. Dellatore,2 William M. Miller,2,3 Phillip B. Messersmith1,3,4*
We report a method to form multifunctional polymer coatings through simple dip-coating of objects in an aqueous solution of dopamine. Inspired by the composition of adhesive proteins in mussels, we used dopamine self-polymerization to form thin, surface-adherent polydopamine films onto a wide range of inorganic and organic materials, including noble metals, oxides, polymers, semiconductors, and ceramics. Secondary reactions can be used to create a variety of ad-layers, including self-assembled monolayers through deposition of long-chain molecular building blocks, metal films by electroless metallization, and bioinert and bioactive surfaces via grafting of macromolecules.
1 Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
2 Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
3 Institute for BioNanotechnology in Medicine, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
4 Materials Science and Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
* To whom correspondence should be addressed. E-mail: [email protected]
