皮膚“鱗狀細(xì)胞癌”(SCC)是用“鈣調(diào)磷酸酶”抑制劑對器官移植患者進(jìn)行免疫抑制治療所產(chǎn)生的一種常見并發(fā)癥,。
這項研究工作發(fā)現(xiàn),，完好的“鈣調(diào)磷酸酶”- NFAT信號作用通道對于抑制SCC發(fā)展很重要，ATF3轉(zhuǎn)錄因子表達(dá)的增加在腫瘤發(fā)生中扮演一個關(guān)鍵角色,。（生物谷Bioon.com）
生物谷推薦原文出處：
Nature doi:10.1038/nature08996
Opposing roles for calcineurin and ATF3 in squamous skin cancer
Xunwei Wu1, Bach-Cuc Nguyen1, Piotr Dziunycz2, Sungeun Chang1,4, Yang Brooks1, Karine Lefort3, Günther F. L. Hofbauer2 & G. Paolo Dotto1,3
1Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
2Department of Dermatology, University Hospital Zurich, Zürich CH-8091
3Department of Biochemistry, University of Lausanne, Epalinges CH-1066, Switzerland
Calcineurin inhibitors such as cyclosporin A (CsA) are the mainstay of immunosuppressive treatment for organ transplant recipients. Squamous cell carcinoma (SCC) of the skin is a major complication of treatment with these drugs, with a 65 to 100-fold higher risk than in the normal population1. By contrast, the incidence of basal cell carcinoma (BCC), the other major keratinocyte-derived tumour of the skin, of melanoma and of internal malignancies increases to a significantly lesser extent1. Here we report that genetic and pharmacological suppression of calcineurin/nuclear factor of activated T cells (NFAT) function promotes tumour formation in mouse skin and in xenografts, in immune compromised mice, of H-rasV12 (also known as Hras1)-expressing primary human keratinocytes or keratinocyte-derived SCC cells. Calcineurin/NFAT inhibition counteracts p53 (also known as TRP53)-dependent cancer cell senescence, thereby increasing tumorigenic potential. ATF3, a member of the ‘enlarged’ AP-1 family, is selectively induced by calcineurin/NFAT inhibition, both under experimental conditions and in clinically occurring tumours, and increased ATF3 expression accounts for suppression of p53-dependent senescence and enhanced tumorigenic potential. Thus, intact calcineurin/NFAT signalling is critically required for p53 and senescence-associated mechanisms that protect against skin squamous cancer development.
