據(jù)巴西科技部網(wǎng)站報(bào)道,，圣保羅大學(xué)醫(yī)療系的科研人員最近取得了利用改造皮膚基因獲取誘導(dǎo)多能干細(xì)胞（iPS細(xì)胞）的科研成果,。
該科研項(xiàng)目的指導(dǎo)教師、圣保羅大學(xué)醫(yī)療系的迪瑪斯·塔德烏·科瓦斯評(píng)價(jià)這項(xiàng)科研成果時(shí)說：“這項(xiàng)研究成果使巴西處于世界科研的突出地位,。”這項(xiàng)由比爾基尼亞·皮坎波和卡斯特羅共同進(jìn)行的博士后科研項(xiàng)目成果發(fā)表在最近出版的《干細(xì)胞與發(fā)育》雜志上。
該項(xiàng)研究的目的是通過在成人細(xì)胞中植入基因以將成人細(xì)胞改造為iPS細(xì)胞,。一些國際上的研究項(xiàng)目也曾使用過這種技術(shù),，但當(dāng)進(jìn)行過基因改造后的iPS細(xì)胞被植入動(dòng)物體內(nèi)后會(huì)導(dǎo)致腫瘤產(chǎn)生。
>>>借著上海世博會(huì)的良好契機(jī),，"第一屆腫瘤基礎(chǔ)和轉(zhuǎn)化醫(yī)學(xué)國際研討會(huì)"將于2010年10月12日在中國上海盛大開幕,，這將為廣大活躍在腫瘤基礎(chǔ)和轉(zhuǎn)化醫(yī)學(xué)第一線的科研工作者提供一個(gè)互動(dòng)交流的平臺(tái)。
會(huì)議官方網(wǎng)站：www.cancerasia.org
此次科研人員在研究過程中使用了SOX2,、C-MYC和另一匿名基因修改人類成人皮膚細(xì)胞,，成功將其改造成了iPS細(xì)胞，并避免了腫瘤的產(chǎn)生,。目前該研究小組正在繼續(xù)努力以揭示出這些細(xì)胞擁有的其他特點(diǎn)以及其潛在的治療功能,。(生物谷Bioon.com)
生物谷推薦原文出處：
Stem Cell And Development doi:10.1089/scd.2009.0424.
Pluripotent reprogramming of fibroblasts by lentiviral-mediated insertion of SOX2, C-MYC and TCL-1A.
Virginia Pican?o-Castro, Elisa Maria Souza Russo-Carbolante, Luiza Junqueira Reis, Ana Maria Fraga, Danielle Aparecida Rosa de Magalh?es, Maristela Delgado Orellana, Rodrigo Alexandre Panepucci, Lygia Veiga Pereira, Dimas Tadeu Covas.
Reprogramming of somatic cells to pluripotency, promises to boost cellular therapy. Most instances of direct reprogramming have been achieved by forced expression of defined exogenous factors using multiple viral vectors. The most used four transcription factors, OCT4, SOX2, KLF4 and C-MYC, can induce pluripotency in mouse and human fibroblasts. Here we report that forced expression of a new combination of transcription factors (TCL-1A, C-MYC and SOX2) is sufficient to promote the reprogramming of human fibroblast into pluripotent cells. These three-factor pluripotent cells are similar to human embryonic stem cells (hESC) in morphology, in the ability to differentiate into cells of the three embryonic layers, and at the level of global gene expression. Induced pluripotent human cells generated by combination of other factors will be of great help for the understanding of reprogramming pathways. This in turn will allow us to better control cell-fate and apply this knowledge to cell therapy.
