研究人員發(fā)現(xiàn)，小RNA家族中非編碼小RNA促進了棕色脂肪組織的形成,，新成果發(fā)表在7月在線出版的《自然—細胞生物學(xué)》期刊上,。在哺乳類動物中，棕色脂肪能燃燒脂肪產(chǎn)生熱量并可預(yù)防肥胖癥,，因此,，新發(fā)現(xiàn)可用于開發(fā)治療肥胖癥和相關(guān)疾病的新方法。
棕色脂肪細胞也稱為脂肪細胞,，分化自可形成肌肉或脂肪的祖源細胞,。Harvey Lodish和同事發(fā)現(xiàn)，在棕色脂肪的形成過程中,，小RNA miR-193b和 miR-365的表達被上調(diào)了,。他們指出，阻斷這些小RNA的功能可阻止棕色脂肪的形成,，同時誘導(dǎo)肌肉相關(guān)標記的表達,。相反，誘導(dǎo)小RNA的表達則阻止了細胞中肌肉的分化并提高了棕色脂肪細胞的形成,。
這些小RNA的功能需要在模式動物中進一步研究,，以鑒別出對付肥胖癥的治療靶標。(生物谷 Bioon.com)
生物谷推薦原文出處：
Nature Cell Biology doi:10.1038/ncb2286
Mir193b–365 is essential for brown fat differentiation
Lei Sun,Huangming Xie, Marcelo A. Mori, Ryan Alexander,Bingbing Yuan,Shilpa M. Hattangadi,Qingqing Liu,C. Ronald Kahn & Harvey F. Lodish
Mammals have two principal types of fat. White adipose tissue primarily serves to store extra energy as triglycerides, whereas brown adipose tissue is specialized to burn lipids for heat generation and energy expenditure as a defence against cold and obesity1, 2. Recent studies have demonstrated that brown adipocytes arise in vivo from a Myf5-positive, myoblastic progenitor by the action of Prdm16 (PR domain containing 16). Here, we identified a brown-fat-enriched miRNA cluster, MiR-193b–365, as a key regulator of brown fat development. Blocking miR-193b and/or miR-365 in primary brown preadipocytes markedly impaired brown adipocyte adipogenesis by enhancing Runx1t1 (runt-related transcription factor 1; translocated to, 1) expression, whereas myogenic markers were significantly induced. Forced expression of Mir193b and/or Mir365 in C2C12 myoblasts blocked the entire programme of myogenesis, and, in adipogenic conditions, miR-193b induced myoblasts to differentiate into brown adipocytes. Mir193b–365 was upregulated by Prdm16 partially through Pparα. Our results demonstrate that Mir193b–365 serves as an essential regulator for brown fat differentiation, in part by repressing myogenesis.
