甲狀腺癌是一種少見(jiàn)的惡性腫瘤,，它的發(fā)病率正在增加,，最近的研究進(jìn)展改進(jìn)了對(duì)于甲狀腺癌發(fā)病機(jī)理的理解。這些改變包括激活普通效應(yīng)基因（包括RET–Ras–BRAF信號(hào)系統(tǒng)和其他獨(dú)特的染色體重排）的遺傳變化鑒定,；作為發(fā)病機(jī)理,，他們中的某些因素與射線照射有關(guān)聯(lián)，轉(zhuǎn)錄因子和黏附分子轉(zhuǎn)錄后調(diào)節(jié)缺陷以及細(xì)胞周期控制元件似乎都影響腫瘤發(fā)展,。這些信息能提供有力的輔助診斷工具,，而且也能用來(lái)鑒別新的治療靶點(diǎn)。
原文出處：Review
英文題目:Pathogenetic mechanisms in thyroid follicular-cell neoplasia
Nature Reviews Cancer 6, 292-306 (April 2006) | doi:10.1038/nrc1836
Pathogenetic mechanisms in thyroid follicular-cell neoplasia
Tetsuo Kondo1,2, Shereen Ezzat2,3 and Sylvia L. Asa1,2 About the author
Top of pageAbstractThyroid cancer is one of the few malignancies that are increasing in incidence. Recent advances have improved our understanding of its pathogenesis; these include the identification of genetic alterations that activate a common effector pathway involving the RET–Ras–BRAF signalling cascade, and other unique chromosomal rearrangements. Some of these have been associated with radiation exposure as a pathogenetic mechanism. Defects in transcriptional and post-transcriptional regulation of adhesion molecules and cell-cycle control elements seem to affect tumour progression. This information can provide powerful ancillary diagnostic tools and can also be used to identify new therapeutic targets.
