生物谷報(bào)道：以色列的一項(xiàng)研究發(fā)現(xiàn),，只有女兒的父親罹患前列腺癌的風(fēng)險(xiǎn)要高于至少有一個(gè)兒子的父親,。這暗示著Y 染色體可能在前列腺癌中發(fā)揮作用,。紐約哥倫比亞大學(xué)的Susan Harlap博士及其同僚在國(guó)家癌癥協(xié)會(huì)1月份的第3期期刊上撰文指出：“從總體上看，盡管其他的解釋還不能被排除在外,，但我們的發(fā)現(xiàn)的確和‘Y 染色體與前列腺癌有聯(lián)系’的假設(shè)是相一致的,。”
在一項(xiàng)家庭研究中，共有38934位父親在從他們子女出生時(shí)開(kāi)始的長(zhǎng)達(dá)40年的追蹤調(diào)查,，其中712位父親最后罹患了前列腺癌,。與至少有一個(gè)兒子的父親相比較，只有女兒的父親罹患前列腺癌的相對(duì)風(fēng)險(xiǎn)值經(jīng)調(diào)整后為1.40 (p < 0.0001),。在有1個(gè),、2個(gè)、3個(gè)或更多孩子的父親中,，無(wú)兒子的父親罹患前列腺癌的相對(duì)風(fēng)險(xiǎn)值分別為1.25,、1.41和1.60。沒(méi)有女兒的父親與兒女雙全的父親相比較，罹患前列腺癌的相對(duì)風(fēng)險(xiǎn)值并無(wú)統(tǒng)計(jì)學(xué)意義上的差異,。
研究者闡述,，“前列腺惡性上皮細(xì)胞中所被觀測(cè)到的最頻繁發(fā)生的細(xì)胞異常”就是Y 染色體的丟失，對(duì)前列腺腫瘤的組織研究是支持Y 染色體與前列腺癌有聯(lián)系的他們還指出,，Y 染色體丟失通常是與其他組織老化相伴隨的,，“在正常前列腺組織內(nèi)一般不會(huì)發(fā)生這種變化，也許因?yàn)樗幕蚴乔傲邢俚靡哉９ぷ鞯母尽?rdquo;“對(duì)男性生殖的進(jìn)一步的研究也許會(huì)給前列腺癌與其他男性特有惡性腫瘤方面的研究指明方向,。”Harlap博士及其同僚這般總結(jié)道,。
原文出處：
Y Chromosome May Have Role in Prostate Cancer
NEW YORK (Reuters Health) Jan 02 - The Y chromosome may be involved in prostate cancer, suggest findings of an Israeli study in which fathers with only daughters had a higher risk of prostate cancer than did fathers with at least one son.
"Overall, our findings are consistent with hypotheses that tie Y chromosome loci to prostate cancer, although other explanations cannot be excluded," write Dr. Susan Harlap of Columbia University, New York, and colleagues in the January 3rd issue of the Journal of the National Cancer Institute.
Among 38,934 fathers in a family-based research cohort who were followed for up to 40 years after the birth of their children, 712 developed prostate cancer.
Compared with men who had at least one son, men with only daughters had an adjusted relative risk of prostate cancer of 1.40 (p < 0.0001).
In men with one, two, or three or more children, the relative risks associated with having no sons were 1.25, 1.41, and 1.60, respectively.
Men with no daughters showed no statistically significant increase or decrease in prostate cancer risk compared with men with both sons and daughters.
Support for the involvement of loci on the Y chromosome in prostate cancer comes from studies of prostate tumor tissue, according to the researchers, who note that loss of the Y chromosome is "the most frequently observed cytogenetic abnormality in malignant prostate epithelium."
And while the Y chromosome is often lost with aging in other tissues, they add, "it is generally preserved in normal prostate tissue, probably because some of its genes are essential for the prostate gland to function normally."
"Further investigation of the reproductive outcomes of men might throw light on prostate cancer and other male-specific malignancies," Dr. Harlap and colleagues conclude.
J Natl Cancer Inst 2007;99:77-81.
http://www.medscape.com/viewarticle/550177
作者簡(jiǎn)介：
Susan Harlap, MB, BS (Distinguished Investigator 2004) of Columbia University, will utilize a unique data resource, the Jerusalem Perinatal Study, based on 92,408 individuals born in 1964-1976, their 43,899 mothers and 43,077 fathers, as well as through links with Israel抯 Psychiatric Registry, to make contacts with subjects, conduct interviews and administer tests of intermediate phenotypes for schizophrenia, sera and DNA. She will also build family sets, ascertain psychiatric disease in parents, separate sporadic cases of schizophrenia from familial cases and study how different subgroups of schizophrenia relate to co-morbidity in the family, through studies of cancer and causes of death. Her long-term goal is to develop the cohort for genetic studies and investigate gene-environment interactions. Prior literature reveals that some candidate genes for schizophrenia, as well as proteins thought to be dysregulated in schizophrenia, involve functional networks that are major players in cancer. Networks involving BRCA1 are especially intriguing. Due to the numerous overlaps within these networks between schizophrenia and oncology, Dr. Harlap will investigate cancer incidence in the families of schizophrenia patients. The occurrence of both diseases in one family, especially if also associated with a birth defect, might facilitate the search for genes. These cohort studies in Jerusalem (COSEM) have the potential to contribute to the discovery of genes for schizophrenia, through the quality and completeness of data through the relative certainty of paternities and through the strong inter-disciplinary team she will utilize.
Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia
