英國萊斯特大學(xué)(University of Leicester)的生醫(yī)學(xué)家已在實(shí)驗(yàn)室證實(shí)米糠(rice bran)能降低腸癌的風(fēng)險(xiǎn)，但目前尚未進(jìn)行人體試驗(yàn),，研究成果發(fā)表于British Journal of Cancer期刊,。
Andreas Gescher教授說：「先前有許多研究已證實(shí)小麥與裸麥糠具有抗癌的特性，但此研究卻是第一個(gè)證明米糠能抗癌的文獻(xiàn),?！乖趯?shí)驗(yàn)室的預(yù)試驗(yàn)中,，研究人員給予受試者每人每天大約200克的米糠食用量，比較了米糠對(duì)乳癌,、前列腺癌及腸癌的效益,，發(fā)現(xiàn)能降低51%的腸胃腺瘤細(xì)胞，而對(duì)乳癌,、前列腺瘤細(xì)胞則沒有抑制作用,，研究人員指出：「米糠能降低腸癌的重點(diǎn)應(yīng)該是米糠內(nèi)的纖維成份，相信未來米糠對(duì)于結(jié)腸直腸癌的預(yù)防大有潛力,?！?/p>
(資料來源 : Bio.com)
部分英文原文：
Translational Therapeutics
British Journal of Cancer (2007) 96, 248-254.
doi:10.1038/sj.bjc.6603539 www.bjcancer.com Published online 9 January 2007
Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis
R D Verschoyle1, P Greaves1, H Cai1, R E Edwards2, W P Steward1 and A J Gescher1
1Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK
2Medical Research Council Toxicology Unit, University of Leicester, Leicester, UK
Correspondence to: Professor AJ Gescher, E-mail: [email protected]
Revised 16 October 2006; accepted 20 November 2006; published online 9 January 2007
Brown rice is a staple dietary constituent in Asia, whereas rice consumed in the Western world is generally white, obtained from brown rice by removal of the bran. We tested the hypothesis that rice bran interferes with development of tumours in TAg, TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) or ApcMin mice, genetic models of mammary, prostate and intestinal carcinogenesis, respectively. Mice received rice bran (30%) in AIN-93G diet throughout their post-weaning lifespan. In TAg and TRAMP mice, rice bran did not affect carcinoma development. In TRAMP or wild-type C57Bl6/J mice, dietary rice bran increased kidney weight by 18 and 20%, respectively. Consumption of rice bran reduced numbers of intestinal adenomas in ApcMin mice by 51% (P<0.01), compared to mice on control diet. In parallel, dietary rice bran decreased intestinal haemorrhage in these mice, as reflected by increased haematocrit. At 10% in the diet, rice bran did not significantly retard ApcMin adenoma development. Likewise, low-fibre rice bran (30% in the diet) did not affect intestinal carcinogenesis, suggesting that the fibrous constituents of the bran mediate chemopreventive efficacy. The results suggest that rice bran might be beneficially evaluated as a putative chemopreventive intervention in humans with intestinal polyps.
Keywords: chemoprevention; diet; rice bran; genetic models of carcinogenesis
