根據紐約路透社報導,，來自賓州大學醫(yī)學院（University of Pennsylvania School of Medicine）的研究人員發(fā)現(xiàn),，常被西方女性用來紓緩更年期癥狀的黑升麻（Black Cohosh），或許也有降低乳癌風險的功能,。此研究發(fā)表于近期的Journal of Cancer期刊,，由Timothy R. Rebbeck主導研究進行。
研究人員對949位乳癌病人進行策試,，并以1524位正常婦女作為對照組,，在服用黑升麻配方（包括5%的黑升麻及2%的白升麻）的婦女中，大約能降低62%的罹癌風險,。此外,，也發(fā)現(xiàn)服用Remifemin（含有20 毫克的黑升麻黃豆片劑，作為調節(jié)婦女更年期之用）的婦女,，也能降低53%的罹癌風險,。
Rebbeck表示：「先前的研究已顯示黑升麻能阻斷細胞的生長,，也能當作抗氧化劑，或作為抗雌激素效應之用,。雖然此研究顯示,，黑升麻對于降低乳癌風險具有顯著功效，但黑升麻也具有副作用,，因此在使用時應特別謹慎,，應在詢問醫(yī)師后再行服用?！?/p>
（編譯/陳瑞娟） (資料來源 : Bio.com)
International Journal of Cancer,，1 April ，2007,， Volume 120, Issue 7 , Pages 1523 - 1528
Epidemiology
A retrospective case-control study of the use of hormone-related supplements and association with breast cancer
Timothy R. Rebbeck 1 2 *, Andrea B. Troxel 1 2, Sandra Norman 1 2, Greta R. Bunin 1 2 3, Angela DeMichele 1 2 4, Mona Baumgarten 5, Michelle Berlin 6, Rita Schinnar 1, Brian L. Strom 1 2 4
1Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA
2Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA
3Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA
4Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA
5Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, MD
6Department of Obstetrics and Gynecology, Center for Women's Health, Oregon Health and Science University, Portland, OR
email: Timothy R. Rebbeck ([email protected])
*Correspondence to Timothy R. Rebbeck, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA
Fax: +1215-573-2265.
Funded by:
National Institutes of Health; Grant Number: P01-CA77596
Keywords
breast cancer ?prevention ?complementary alternative medicine
Abstract
Hormone-related supplements (HRS), many of which contain phytoestrogens, are widely used to manage menopausal symptoms, yet their relationship with breast cancer risk has generally not been evaluated. We evaluated whether use of HRS was associated with breast cancer risk, using a population-based case-control study in 3 counties of the Philadelphia metropolitan area consisting of 949 breast cancer cases and 1,524 controls. Use of HRS varied significantly by race, with African American women being more likely than European American women to use any herbal preparation (19.2% vs. 14.7%, p = 0.003) as well as specific preparations including black cohosh (5.4% vs. 2.0%, p = 0.003), ginseng (12.5% vs. 7.9%, p < 0.001) and red clover (4.7% vs. 0.6%, p < 0.001). Use of black cohosh had a significant breast cancer protective effect (adjusted odds ratio 0.39, 95% CI: 0.22-0.70). This association was similar among women who reported use of either black cohosh or Remifemin (an herbal preparation derived from black cohosh; adjusted odds ratio 0.47, 95% CI: 0.27-0.82). The literature reports that black cohosh may be effective in treating menopausal symptoms, and has antiestrogenic, antiproliferative and antioxidant properties. Additional confirmatory studies are required to determine whether black cohosh could be used to prevent breast cancer. © 2006 Wiley-Liss, Inc.
