生物谷報(bào)道：AKT/蛋白激酶 B信號(hào)作用通道調(diào)控細(xì)胞增殖和生長,，參與包括細(xì)胞凋亡和葡萄糖代謝在內(nèi)的細(xì)胞過程,。雖然在其他通道構(gòu)成部分中也發(fā)現(xiàn)了激發(fā)突變的現(xiàn)象，而以前卻不知道有激發(fā)癌癥的AKT點(diǎn)突變,。但是現(xiàn)在,，研究人員已經(jīng)在人類乳腺癌、結(jié)腸直腸癌和卵巢癌中發(fā)現(xiàn)了AKT1中的一個(gè)突變,，該突變通過增強(qiáng)其膜聯(lián)系作用來激發(fā)這種激酶,，從而將AKT1與癌癥的發(fā)生直接關(guān)聯(lián)了起來。這項(xiàng)研究結(jié)果發(fā)表在最新一期的《自然》雜志上,。
原文出處：
Volume 448 Number 7152
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer p439
John D. Carpten, Andrew L. Faber, Candice Horn, Gregory P. Donoho, Stephen L. Briggs, Christiane M. Robbins, Galen Hostetter, Sophie Boguslawski, Tracy Y. Moses, Stephanie Savage, Mark Uhlik, Aimin Lin, Jian Du, Yue-Wei Qian, Douglas J. Zeckner, Greg Tucker-Kellogg, Jeffrey Touchman, Ketan Patel, Spyro Mousses, Michael Bittner, Richard Schevitz, Mei-Huei T. Lai, Kerry L. Blanchard & James E. Thomas
doi:10.1038/nature05933
Abstract | Full Text | PDF (1,310K) | Supplementary information
See also: Editor's summary
相關(guān)基因：
AKT1
Official Symbol AKT1 and Name: v-akt murine thymoma viral oncogene homolog 1 [Homo sapiens]
Other Aliases: AKT, MGC99656, PKB, PRKBA, RAC, RAC-ALPHA
Other Designations: RAC-alpha serine/threonine-protein kinase; murine thymoma viral (v-akt) oncogene homolog-1; protein kinase B; rac protein kinase alpha
Chromosome: 14; Location: 14q32.32
Annotation: Chromosome 14, NC_000014.7 (104306731..104333125, complement)
MIM: 164730
GeneID: 207
作者簡介：
James E. Thomas, PhD
Job Title: Associate Professor in the Department of Biological Sciences
Employer: University of Lethbridge
Place of Birth: Peterborough, Ontario, Canada
Public School attended: Immaculate Conception
High School attended: St. Peter's
Further Education: McMaster University (B.Sc., Ph.D.).
Geographic focus of research: Alberta, USA
Brief synopsis of current research:
DNA fingerprinting of trout and walleye: A study of the distribution and evolution of trout and walleye in Western Canada and northern United States.
Assessment of Water Quality: A study of microbial contamination of surface and ground waters in southern Alberta, a region which uses extensive irrigation to support forage, grain, potatoe, sugar beet, oil seed and intensive livestock farming operations. This is a new initiative that has been developing over the past two years.
Recent Publications:
Thomas, J.E., Prozniak, C., Sandham, R., Kirk, H., Chew, L. and Buchwald, V. Genetic variation in populations of walleye (Stizostedion vitreum) from Central Alberta. Alberta Fisheries Management Enhancement Program and the Alberta Conservation Association, P.O. Box 40027, Baker Centre Postal Outlet, Edmonton, AB, T5J 4M9, Canada, 1999.
Thomas, J.E., Sandham, R., Pienkowski, C., Gonci, D., Chee, G., Groft, D., Chew, L., Clayton, T. and Fitch, L. Genetic variation in populations of bull trout (Salvelinus confluentus) from Glacier National Park. Report to the U.S. National Park Service, Glacier National Park, West Glacier, Mt 59936, U.S.A., 1997.
Thomas, J.E., Sandham, R., Pienkowski, C., Gonci, D., Chee, G., Groft, D., Chew, L., Clayton, T. and Fitch, L. Genetic variation in populations of bull trout (Salvelinus confluentus) from Alberta. Report to Alberta Fisheries Management Enhancement Program, Alberta Conservation Association, P.O. Box 40027, Baker Centre Postal Outlet, Edmonton, AB, T5J 4M9, Canada, 1997.
Comments:
Water is one of the most important resources that we have on this planet. Maintenance of plentiful and healthy water resources in Canada for use in industrial, agricultural and domestic applications will require a concerted effort on our part to understand the physical, chemical and biological parameters that affect water quality and quantity within the Nation.
