2008年2月的愛思唯爾期刊《胃腸道內(nèi)鏡》（Gastrointestinal Endoscopy）刊登了日本自治醫(yī)科大學(xué)的一項最新研究，研究表明采用最佳光譜顯像（OBI）系統(tǒng)內(nèi)鏡能夠有效地診斷出凹陷型早期胃癌,。
胃癌是最常見的惡性腫瘤之一，胃癌的早期發(fā)現(xiàn)和早期診斷是及早治療的基礎(chǔ),，也是降低胃癌死亡率的關(guān)鍵一環(huán),。癌組織浸潤僅限于粘膜層及粘膜下層者均屬早期胃癌,，判斷早期胃癌的標準不是其面積大小而是其深度,，故早期胃癌也稱為粘膜內(nèi)癌或表淺擴散性癌。早期胃癌經(jīng)手術(shù)切除治療,，預(yù)后頗為良好,，術(shù)后5年存活率可達90％,。早期表淺型胃癌腫瘤表面較平坦，隆起不顯著,，其肉眼形態(tài)可分為3種類型：隆起型,，平坦型和凹陷型（又名癌性糜爛）。與正常組織相比,，凹陷型早期胃癌在顏色和形狀上僅有微小變化,，內(nèi)窺鏡診斷起來相對比較困難。
最新研究顯示,，最佳光譜顯像（OBI）內(nèi)鏡系統(tǒng)能從普通內(nèi)鏡顯像中重建出非常好的光譜影像，這種顯像技術(shù)原理是基于通過應(yīng)用光譜估算技術(shù)在算術(shù)上縮短常規(guī)圖像的帶寬。采用該系統(tǒng)診斷凹陷型早期胃癌,，其分界線能很容易的通過不用放大的最佳光譜圖像來識別，因為在內(nèi)鏡下能明顯地觀察到癌組織的淡紅色圖像和周圍正常組織的淡黃色圖像的清楚的分界,。
研究人員認為,，同傳統(tǒng)的內(nèi)鏡系統(tǒng)相比，OBI系統(tǒng)在診斷凹陷型早期胃癌更為有效,，具有廣闊的發(fā)展和應(yīng)用前景,。(科學(xué)網(wǎng) 于乃森/編譯)
生物谷推薦原始出處：
（Gastrointestinal Endoscopy），doi:10.1016/j.gie.2007.06.067,，Hiroyuki Osawa, Kentaro Sugano
Optimal band imaging system can facilitate detection of changes in depressed-type early gastric cancer
Hiroyuki Osawa MD, Mitsuyo Yoshizawa MD, Hironori Yamamoto MD, Hiroto Kita MD, Kiichi Satoh MD, Hirohide Ohnishi MD, Hidetoshi Nakano MD, Masahiro Wada MD, Masayuki Arashiro MD, Mamiko Tsukui MD, Kenichi Ido MD and Kentaro Sugano MD
Background
The endoscopic diagnosis of depressed-type early gastric cancers is difficult because these cancers manifest as subtle changes in color and shape. The newly developed optimal band imaging (OBI) system can reconstruct the best spectral images derived from ordinary endoscopic images and enhances the mucosal surface without the use of dyes. This imaging technique is based on narrowing the bandwidth of conventional image arithmetically by using spectral estimation technology.
Objective
Evaluation of the usefulness of the OBI system for identifying the demarcation line of depressed-type early gastric cancers.
Design
Prospective study.
Setting
Jichi Medical University in Japan.
Patients
Twenty-seven cases with depressed-type early gastric cancer.
Main Outcome Measurement
Comparative study for the success rate of identifying the demarcation line of depressed-type early gastric cancer by using optimal band images and conventional endoscopic images.
