生物谷報道：美國紐約Rochester大學(xué)的研究人員首次證實,，一種存在于葡萄皮和紅酒中的天然抗氧化物通過到達細胞的動力工程線粒體,，能夠幫助摧毀胰腺癌細胞。這項研究的結(jié)果發(fā)表在3月的Advances in Experimental Medicine and Biology雜志上,。
研究還證實，當胰腺癌細胞受到抗氧化物質(zhì)白藜蘆醇和輻射的雙重聯(lián)合時,，這種聯(lián)合能誘導(dǎo)發(fā)生細胞死亡,。
研究的領(lǐng)導(dǎo)者 Paul Okunieff, MD博士指出，這項研究對患者有多重意義,，這項新研究顯示,，白藜蘆醇不但能夠到達所希望的靶標，而且還能破壞惡性細胞的連接,，并且同時保護受害的正常組織不受放射的有害影響,。
研究的領(lǐng)導(dǎo)者Paul Okunieff博士指出，這項研究對患者有多重意義,，這項新研究顯示,，白藜蘆醇不但能夠到達所希望的靶標，而且還能破壞惡性細胞的連接,，并且同時保護受害的正常組織不受放射的有害影響,。
注：Rochester大學(xué)位于美國紐約州西部安大略湖南岸，是私立綜合研究型大學(xué),，根據(jù)us news的綜合排名為全美前四十名,，其下所屬的伊士曼音樂學(xué)院（eastman school of music）為全美最佳的音樂學(xué)院，以學(xué)理與演奏藝術(shù)兼重著稱,；賽門商業(yè)管理學(xué)院（simon graduate school of business administration）是全美前三十名的商學(xué)院,；labortory for laser energetics擁有全球最大功率的雷射；而醫(yī)學(xué)院亦有甚佳的風評,，尤其在臨床醫(yī)學(xué)的表現(xiàn),；所附設(shè)置思壯紀念醫(yī)院是紐約西部最大的醫(yī)學(xué)中心,。除此之外，光學(xué),，經(jīng)濟學(xué),，政治學(xué)，心理學(xué)等學(xué)科也都是著名的科系強項,。羅切斯特理工學(xué)院則以大學(xué)本科教育與專精職業(yè)訓(xùn)練聞名,，光學(xué)攝影與影像處理十分聞名。另設(shè)置了國家聾啞高等教育中心,，是專供美國聾啞殘障人士就學(xué)的高等教育機構(gòu),。
英文原文鏈接：http://www.foodnavigator.com/news/ng.asp?n=84238-resveratrol-red-wine-cancer
生物谷推薦原始出處：
Advances in Experimental Medicine and Biology
2008;614:179-86
Anti-cancer effect of resveratrol is associated with induction of apoptosis via a mitochondrial pathway alignment
Authors: Paul Okunieff, Weimin Sun, Wei Wang, Jung Kim, Shanmin Yang
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Resveratrol, a phytoalexin found in the skin of grapes, is believed to have multiple bioactivities including anti-cancer, anti-carcinogenesis and antiinflammatory. The mechanisms by which resveratrol might produce these effects are not well understood. In this study, malignant human pancreatic cancer cells were treated without or with resveratrol in combination with ionizing radiation (IR), and then the mitochondrial function of treated cells was evaluated using several standardized assays. They include the Calcein AM method for mitochondria transition pore; the JC-1 staining method for mitochondria membrane potential; the CM-H2DCFDA method for reactive oxygen species; and the Annexin V/propidium iodide (PI) method for apoptosis/cell death. Our results indicated that (1) pore function was partially intact after resveratrol, but resveratrol probably interfered with the accumulation of intracellular Calcein AM; (2) depolarization of the mitochondria membrane was increased in the resveratrol treated cells, consistent with mitochondrial dysfunction; (3) ROS was slightly increased with resveratrol, a phenomenon that was greatly increased when this agent was combined with IR; and (4) in parallel with the above changes in mitochondrial and drug transport, cells treated with resveratrol showed increased apoptosis as measured by Annexin V/PI staining. In summary, the anti-cancer effect of resveratrol is associated with the damage of mitochondrial function that leads to increased ROS, apoptosis, and possibly intracellular drug accumulation via inhibition of proteins involved in multi-drug resistance (MDR).
PMID: 18290328 [PubMed - in process]
