據(jù)10月1日刊JAMA上的一則研究披露,，某種由脂肪細(xì)胞分泌的蛋白質(zhì)激素的基因變異與結(jié)腸直腸癌風(fēng)險的減少有關(guān)聯(lián),。
根據(jù)文章的背景資料，有數(shù)項研究已經(jīng)顯示了在肥胖癥與結(jié)腸直腸癌風(fēng)險之間具有相關(guān)性,。脂聯(lián)素（Adiponectin）是一種由脂肪組織分泌的激素,，而血清中脂聯(lián)素的水平與肥胖癥和胰島素的高濃度呈反向相關(guān),。文章的作者寫道：“盡管有證據(jù)顯示,，循環(huán)中的脂聯(lián)素濃度與結(jié)腸直腸癌風(fēng)險之間存在相關(guān)性，但是有關(guān)脂聯(lián)素通路和結(jié)腸直腸癌的基因之間的關(guān)聯(lián)性目前則尚無報導(dǎo) ,。”
Feinberg School of Medicine, Northwestern University, Chicago的Virginia G. Kaklamani, M.D., D.Sc.及其同僚開展了一項研究,，旨在確定脂聯(lián)素（ADIPOQ）和脂聯(lián)素受體 1（ADIPOR1）的基因變異與結(jié)腸直腸癌風(fēng)險之間的相關(guān)性。該項研究由2個病例對照研究所組成,，其中包括被診斷患有結(jié)腸直腸癌的病人組和沒有結(jié)腸直腸癌的對照組,。病例對照研究-1包括總數(shù)441名結(jié)腸直腸癌患者的小組和658名沒有該癌癥的對照組；這2組人都有Ashkenazi Jewish血統(tǒng),，他們都來自紐約,。病例對照研究-2包括來自芝加哥的199名結(jié)腸直腸癌患者和199名的對照組人士，他們在性別,、年齡和種族上的比例皆為1:1,。
研究人員寫道：“在這一基于臨床的病例對照分析中,，我們發(fā)現(xiàn)，在2個單獨(dú)的病例對照研究中以及在進(jìn)行了年齡,、性別和其它SNPs校正之后的對這2項研究進(jìn)行合并后的分析中,，ADIPOQ 基因 (rs266729)中的一種單核苷酸多態(tài)性 [SNP; 這是一種基因變異 ] 與結(jié)腸直腸癌風(fēng)險之間存在著一種相關(guān)性。”
他們補(bǔ)充說,，這些發(fā)現(xiàn)提示ADIPOQ 基因可能容納有容易改變結(jié)腸直腸癌風(fēng)險的SNPs/突變,。 “如果這些令人興奮的結(jié)果能夠在其它的研究中獲得證實的話，脂聯(lián)素軸心可能會成為結(jié)腸直腸癌風(fēng)險的一種重要的調(diào)節(jié)因子,。人們需要在未來從事有關(guān)脂聯(lián)素的可能的影響及其SNPs在結(jié)腸直腸癌預(yù)后中的研究,，并且還可以將其并入該疾病的遺傳風(fēng)險模型之中。”（生物谷Bioon.com）
生物谷推薦原始出處：
JAMA. 2008;300(13):1523-1531.
Variants of the Adiponectin (ADIPOQ) and Adiponectin Receptor 1 (ADIPOR1) Genes and Colorectal Cancer Risk
Virginia G. Kaklamani; Kari B. Wisinski; Maureen Sadim; Cassandra Gulden; Albert Do; Kenneth Offit; John A. Baron; Habibul Ahsan; Christos Mantzoros; Boris Pasche
Context Current epidemiological evidence suggests an association between obesity, hyperinsulinemia, and colorectal cancer risk. Adiponectin is a hormone secreted by the adipose tissue, and serum levels are inversely correlated with obesity and hyperinsulinemia. While there is evidence of an association between circulating adiponectin levels and colorectal cancer risk, no association between genes of the adiponectin pathway and colorectal cancer have been reported to date.
Objective To determine the association of 10 haplotype-tagging single-nucleotide polymorphisms (SNPs) of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes with colorectal cancer risk.
Design, Setting, and Patients Two case-control studies including patients with a diagnosis of colorectal cancer and controls were recruited between 2000 and 2007. Case-control study 1 included a total of 441 patients with a diagnosis of colorectal cancer and 658 controls; both groups were of Ashkenazi Jewish ancestry and from New York, New York. Case-control study 2 included 199 patients with a diagnosis of colorectal cancer and 199 controls from Chicago, Illinois, matched 1:1 for sex, age, and ethnicity.
Main Outcome Measures ADIPOQ and ADIPOR1 SNP frequency among cases and controls.
Results In study 1, after adjustment for age, sex, and SNPs from the same gene, 3 ADIPOQ SNPs and 1 ADIPOR1 SNP were associated with colorectal cancer risk: rs266729 (adjusted odds ratio [AOR], 0.72; 95% confidence interval [CI], 0.55-0.95) and rs822396 (AOR, 0.37; 95% CI, 0.14-1.00) were associated with decreased risk whereas rs822395 (AOR, 1.76; 95% CI, 1.09-2.84) and rs1342387 (AOR, 1.79; 95% CI, 1.18-2.72) were associated with increased risk. In study 2, after adjustment for age, sex, race, and SNPs from the same gene, the ADIPOQ SNP rs266729 was associated with a decreased colorectal cancer risk of similar magnitude as in study 1 (AOR, 0.52; 95% CI, 0.34-0.78). Combined analysis of both studies shows an association of rs266729 with decreased colorectal cancer risk (AOR, 0.73; 95% CI, 0.53-0.99).
Conclusion The SNP rs266729, which tags the 5' flanking region of the ADIPOQ gene, is associated with decreased colorectal cancer risk.
