科學(xué)家以往研究認(rèn)為,，經(jīng)常食用含有粗纖維食品,，例如全麥面包可以減少腸癌的發(fā)病率。最新研究成果顯示,，或許起到防癌作用的是烘烤過(guò)的面包皮,。但研究人員說(shuō)，現(xiàn)在就說(shuō)每天吃多少面包皮可預(yù)防腸癌為時(shí)尚早,。
8月號(hào)《歐洲癌癥預(yù)防雜志》刊登研究報(bào)告說(shuō),，面包中對(duì)人體最有益的成分不是纖維質(zhì)而是面包皮。這是因?yàn)樵诤婵久姘^(guò)程中會(huì)產(chǎn)生一種被稱為Pronyl-lysine的抗氧化劑,，這種物質(zhì)可以預(yù)防腸癌,，而它主要集中在面包皮中。
印度安納馬萊大學(xué)研究人員通過(guò)小白鼠試驗(yàn)檢測(cè)出了Pronyl-lysine的確切作用,。
研究人員把小白鼠暴露在可以引發(fā)腸癌的化學(xué)環(huán)境中,，同時(shí)給予不同組別的白鼠含有Pronyl-lysine的面包皮。經(jīng)過(guò)觀察測(cè)算,，科學(xué)家發(fā)現(xiàn),，每天食用面包皮的小白鼠早期癌癥病變的幾率降低了72％。
英國(guó)《每日郵報(bào)》21日援引研究人員的話說(shuō)：“實(shí)驗(yàn)表明,，持續(xù)吸收Pronyl-lysine可以顯著降低早期癌變的幾率,。”（生物谷Bioon.com）
生物谷推薦原始出處：
European Journal of Cancer Prevention:doi: 10.1097/CEJ.0b013e32832945a6
Inhibitory effect of bread crust antioxidant pronyl-lysine on two different categories of colonic premalignant lesions induced by 1,2-dimethylhydrazine
Panneerselvam, Jayabal; Aranganathan, Selvaraj; Nalini, Namasivayam
Colorectal malignancies continue to be one of the most frequent and life-threatening diseases throughout the world. Pronyl-lysine, a product obtained from bread crust, is a potent free radical scavenging antioxidant exerting chemopreventive activity by reducing oxidative stress. This study was conducted to investigate the effects of pronyl-lysine supplementation on the formation of colonic precancerous lesions, circulatory lipid peroxidation, and enzymic antioxidant status in 1,2-dimethylhydrazine-induced colon carcinogenesis. Male Wistar rats were randomized into seven groups; group 1 was control rats, group 2 received pronyl-lysine (2 mg/kg body weight orally) everyday, rats in groups 3-7 were administered subcutaneous 1,2-dimethylhydrazine (20 mg/kg body weight) once a week for 15 consecutive weeks. In addition, group 4 (pre-initiation), 5 (initiation), 6 (post-initiation), and 7 (entire period) received pronyl-lysine (2 mg/kg body weight orally) everyday. At the end of 34 weeks, indicative markers of lipid peroxidation and changes in antioxidant defense system were measured in circulation. The results showed that 1,2-dimethylhydrazine significantly increased total aberrant crypt foci formation, total number of dysplastic foci, β-catenin accumulated crypts and proliferating cell nuclear antigen labeling index in the colon, and enhanced lipid peroxidation markers and decreased enzymic antioxidant activities in the plasma and erythrocyte lysate as compared with untreated controls. Pronyl-lysine supplementation significantly reversed the changes as compared with the rats treated with 1,2-dimethylhydrazine alone. The effect of pronyl-lysine was more pronounced when supplemented throughout the study period (group 7). These findings suggest that pronyl-lysine suppresses 1,2-dimethylhydrazine-induced colon carcinogenesis effectively.
