生物谷訊：10月23日，乳腺癌研究領(lǐng)域?qū)I(yè)雜志《乳腺癌研究和治療》（Breast Cancer Research and Treatment）在線發(fā)表了中科院上海生命科學(xué)研究院營養(yǎng)所王慧研究員等的一項(xiàng)關(guān)于維生素D和鈣的攝入量對(duì)女性乳腺癌風(fēng)險(xiǎn)關(guān)系的Meta-analysis研究成果,。研究表明高水平的維生素D和鈣的攝入能夠顯著降低女性患有乳腺癌的風(fēng)險(xiǎn),，血清中25-羥維生素D(25(OH)D)水平和患乳腺癌風(fēng)險(xiǎn)呈顯著負(fù)相關(guān)，而血清中維生素D的活性形式1α,25-二羥維生素D（1α,，25(OH)2D）水平和患乳腺癌風(fēng)險(xiǎn)無關(guān),。
研究發(fā)現(xiàn)，通過膳食或營養(yǎng)補(bǔ)充的高維生素D攝入人群比低攝入人群發(fā)生乳腺癌的風(fēng)險(xiǎn)顯著降低9%（RR = 0.91,，95% CI = 0.85-0.97）,；血清中25(OH)D處于最高水平的女性患有乳腺癌的風(fēng)險(xiǎn)比血清中最低25(OH)D水平的女性低近45%（OR = 0.55, 95% CI = 0.38-0.80）；而血清中1α,，25(OH)2D水平的高低和患乳腺癌風(fēng)險(xiǎn)沒有關(guān)聯(lián)（OR = 0.99,，95% CI = 0.68-1.44）。同時(shí)發(fā)現(xiàn),，高鈣攝入比低鈣攝入的女性患乳腺癌的風(fēng)險(xiǎn)低19%（RR = 0.81,，95% CI = 0.72-0.90）。該研究成果表明維生素D和鈣在乳腺癌預(yù)防中的重要作用,，提示女性日常生活中要注意通過營養(yǎng)膳食,、多曬太陽等多渠道補(bǔ)充足夠的維生素D和鈣，以降低乳腺癌發(fā)生的風(fēng)險(xiǎn),。
本課題得到了中科院百人計(jì)劃,、營養(yǎng)所所長基金、國家自然科學(xué)基金委等資助,。（生物谷Bioon.com）
生物谷推薦原始出處：
Breast Cancer Research and Treatment DOI:10.1007/s10549-009-0593-9
Meta-analysis of vitamin D, calcium and the prevention of breast cancer
Peizhan Chen1, 2, Pingting Hu1, 2, Dong Xie1, 2, Ying Qin1, 2, Fudi Wang1, 2 and Hui Wang1, 2
(1) Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Rm 427, 41# Building, 320 Yueyang Road, 200031 Shanghai, People’s Republic of China
(2) Graduate School of the Chinese Academy of Sciences, 200031 Shanghai, People’s Republic of China
Abstract Vitamin D and calcium intake have been suggested to have protective effects against breast cancer; however, the data have been inconclusive. The present meta-analysis examined the overall effects of vitamin D intake, circulating 25(OH)D and 1α,25(OH)2D levels, and calcium intake on breast cancer risk. Data from 11 studies on vitamin D intake, 7 studies on circulating 25(OH)D levels, 3 studies of circulating 1α,25(OH)2D levels, and 15 studies on calcium intake and breast cancer risk were included in this analysis. From the meta-analysis, there was a significant inverse relationship between vitamin D intake and breast cancer risk, with an overall relative risk (RR) of high versus low vitamin D intake for breast cancer of 0.91 (95% CI = 0.85–0.97). The highest quantile of circulating 25(OH)D was found to be associated with a 45% (OR = 0.55, 95% CI = 0.38–0.80) decrease in breast cancer when compared with the lowest quantile. No significant association for the circulating 1α,25(OH)2D level and breast cancer was found (OR = 0.99, 95% CI = 0.68–1.44). For calcium, a 19% (RR = 0.81, 95% CI = 0.72–0.90) decrease in breast cancer risk was found for those with highest quantile of calcium intake compared to the lowest quantile. These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer.
