目前研發(fā)安全有效的腫瘤靶向治療的納米探針是一項(xiàng)極具挑戰(zhàn)性的任務(wù)。來(lái)自上海交通大學(xué),，安徽醫(yī)科大學(xué)的研究人員研發(fā)出一種生物相容性好,、靶向性好、生物安全性高的智能化的納米探針,，這種探針能準(zhǔn)確識(shí)別活體腫瘤細(xì)胞與腫瘤中的新生血管內(nèi)皮細(xì)胞,，在近紅外激光照射下，能選擇性殺死腫瘤細(xì)胞,，顯著延長(zhǎng)荷瘤小鼠的生存期,。這一研究成果公布在《分子制藥學(xué)》（Molecular pharmaceutics）上。
研究組采用樹(shù)形分子取代金納米棒表面毒性分子CTAB,，顯著提高了金納米棒的生物相容性,，并將RGD多肽與樹(shù)形分子表面基團(tuán)偶聯(lián)，成功構(gòu)建一種新型的靶向性納米探針,。實(shí)驗(yàn)表明,，這種新穎的智能化納米探針能準(zhǔn)確識(shí)別活體腫瘤細(xì)胞與腫瘤中的新生血管內(nèi)皮細(xì)胞,，在近紅外激光照射下，能選擇性殺死腫瘤細(xì)胞,，顯著延長(zhǎng)荷瘤小鼠的生存期,。這種智能化的納米探針在未來(lái)的腫瘤早期探測(cè)，分子影像與靶向治療方面具有潛在的應(yīng)用價(jià)值,。（生物谷Bioon.com）
生物谷推薦原始出處：
Mol. Pharmaceutics,DOI: 10.1021/mp9001415
RGD-Conjugated Dendrimer-Modified Gold Nanorods for in Vivo Tumor Targeting and Photothermal Therapy
Zhiming Li?§, Peng Huang§, Xuejun Zhang*, Jing Lin#, Sen Yang, Bing Liu, Feng Gao, Peng Xi?, Qiushi Ren*? and Daxiang Cui*
Institute for Laser Medicine & Biophotonics, School of Life Sciences and Biotechnology, and National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China, Institute of Dermatology & Department of Dermatology at No. 1 Hospital, Anhui Medical University, the Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education, Hefei 230032, China, and College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
Successful development of safe and effective nanoprobes for tumor targeting and selective therapy is a challenging task. Although gold nanorods(GNRs) have the potential to perform such a role, the toxicity of surfactant cetyltrimethylammonium bromides (CTAB) on their surfaces limits their applications. Here, polyamidoamine dendrimer was applied to replace CTAB molecules on the surface of gold nanorods. When the resultant dendrimer-modified gold nanorods conjugated with arginine-glycine-aspartic acid (RGD) peptides, they showed highly selective targeting and destructive effects on the cancer cells and solid tumors under near-infrared laser irradiation. Also, we successfully observed the disappearance of tumors implanted in four sample mice from test group of ten. High-performance RGD-conjugated dendrimer-modified GNR nanoprobes exhibit great potential in applications such as tumor targeting, imaging, and selective photothermal therapy.
