據(jù)一項新的研究顯示，規(guī)律攝入阿司匹林可使罹患皮膚癌風險降低40%,。
哈佛大學醫(yī)學院的科學家們證實,，每日服用止痛藥，至少5年,，可降低罹患黑色素瘤的風險,。
“我們的數(shù)據(jù)至少支持這一假設——長期穩(wěn)定地服用阿司匹林有效果，”每日郵報引述共同作者Robert Stern博士告訴MSNBC的話說,。
研究人員分析和比較了1000人的醫(yī)療紀錄,，不料竟發(fā)現(xiàn)其中有400人被確診黑色素瘤。黑色素瘤是最致命的皮膚癌類型,。
另一方面,，發(fā)現(xiàn)未患黑色素瘤的人均有服用如阿司匹林等非甾體抗炎藥（NSAIDS）較長時間的用藥史。
然而,，來自加州大學舊金山分校的Maryam Asgari博士反駁該項研究說,，她未發(fā)現(xiàn)任何關于支持NSAID對降低罹患皮膚癌風險有作用的證據(jù)。
這項研究發(fā)表在《Journal of Investigative Dermatology》上,。（生物谷Bioon.com）
生物谷推薦原文出處：
Journal of Investigative Dermatology doi:10.1038/jid.2011.58
Long-Term Use of Nonsteroidal Anti-inflammatory Drugs Decreases the Risk of Cutaneous Melanoma: Results of a United States Case–Control Study
Clara Curiel-Lewandrowski, Tamar Nijsten, Maria L Gomez, Loes M Hollestein, Michael B Atkins and Robert S Stern
Experimental and observational studies continue to demonstrate conflicting results regarding the role of several commonly used drugs as melanoma chemopreventive agents. This case–control study was designed to assess the associations between cutaneous melanoma (CM) and exposure to nonsteroidal anti-inflammatory drugs (NSAIDs) and statins in current users. A total of 400 CM and 600 eligible age- and gender-matched community-based controls were prospectively recruited and interviewed. We assessed participants’ demographic characteristics, CM risk factors, and current and previous use of medications. Multivariable conditional logistic regression models were used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for associations between NSAIDs and/or aspirin (ASA), statin exposure, and CM risk. Half of the subjects were men (mean age 60 years). After adjusting for confounders, use of any type of NSAIDs for more than 5 years significantly reduced the risk of melanoma development compared with the low-exposure group (adjusted OR=0.57; 95% CI=0.43–0.77). Subgroup analyses showed that the observed risk reduction was primarily driven by continuous ASA use (>5 years adjusted OR=0.51, 95% CI=0.35–0.75). No significant protective effect was observed with statin exposure (OR=0.97, 95% CI=0.73–1.29). Long-term use of NSAIDs, especially ASA, is associated with a significantly decreased risk of CM development. Clinical intervention studies are warranted to further investigate the potential role of ASA and other NSAIDs as chemopreventive agents for CM.
