納什維爾范德堡大學醫(yī)學中心的Mary Zutter和同事們已經(jīng)得到相關(guān)數(shù)據(jù),，這些數(shù)據(jù)顯示蛋白α-2整合素的減少表達可預測腫瘤的遠端傳播,、乳腺癌或前列腺癌患者的降低的存活率,。
研究人員首次研究了蛋白α-2-β-1整合素（由α-2整合素蛋白與β-1整合素蛋白復合而成）在癌癥引發(fā)與進展中的作用，研究中應用乳腺癌進展與轉(zhuǎn)移（擴散）的臨床相關(guān)的自發(fā)的小鼠模型,。他們的數(shù)據(jù)表明,，α-2-β-1整合素抑制轉(zhuǎn)移。
為研究這些數(shù)據(jù)是否有直接的臨床應用性,，進行了人乳腺癌與前列腺癌的芯片數(shù)據(jù)庫系統(tǒng)分析,。分析結(jié)果表明，負責產(chǎn)生α-2整合素的基因的表達降低可預測轉(zhuǎn)移與存活降低,，也就是暗示α-2整合素表達可作為一個有用的轉(zhuǎn)移潛在性與患者存活的生物標志物,。
研究發(fā)表在《臨床研究雜志》上。（生物谷bioon.com)
doi:10.1172/JCI42328
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The α2β1 integrin is a metastasis suppressor in mouse models and human cancer.
Ramirez NE, Zhang Z, Madamanchi A, Boyd KL, O'Rear LD, Nashabi A, Li Z, Dupont WD, Zijlstra A, Zutter MM.
Abstract Integrins regulate cell-cell and cell-matrix adhesion and thereby play critical roles in tumor progression and metastasis. Although work in preclinical models suggests that β1 integrins may stimulate metastasis of a number of cancers, expression of the β1 subunit alone has not been shown to be a useful prognostic indicator in human cancer patients. Here we have demonstrated that the α2β1 integrin suppresses metastasis in a clinically relevant spontaneous mouse model of breast cancer. These data are consistent with previous studies indicating high expression of α2β1 integrin in normal breast epithelium and loss of α2β1 in poorly differentiated breast cancer. They are also consistent with our systematic analysis of microarray databases of human breast and prostate cancer, which revealed that decreased expression of the gene encoding α2 integrin, but not genes encoding α1, α3, or β1 integrin, was predictive of metastatic dissemination and decreased survival. The predictive value of α2 expression persisted within both good-risk and poor-risk cohorts defined by estrogen receptor and lymph node status. Thus, the α2β1 integrin functionally inhibits breast tumormetastasis, and α2 expression may serve as an important biomarker of metastatic potential and patient survival.
