臨床上,，乳腺片密度是乳腺癌危險的重要標志物之一,。乳腺片密度的增加，女性罹患乳腺癌的風險易增加,。雖然多年來，乳腺片密度對乳腺癌的作用被熟知,，但至于哪些參數(shù)會影響乳腺片密度至今仍不甚明了,。
最近，乳腺癌研究和治療雜志刊登的一項新研究著重分析了哪些參數(shù)會對乳腺片密度造成影響,。重點考察了女性在經(jīng)歷某些胎兒出生時期和嬰兒時期,，哪些參數(shù)影響了乳腺片的密度。
該研究共納入3,574名年齡在45至68歲之間的女性,，研究結(jié)果顯示39歲以上的高齡產(chǎn)婦以及青春期前高瘦的成年女性在乳腺片密度上較高,。研究發(fā)現(xiàn)乳腺片密度在75%或以上的女性在罹患乳腺癌的風險上是乳腺片密度低的女性的5倍。
研究人員解釋：女性持續(xù)暴露在激素以及各種生長因子的環(huán)境下,，乳腺組織會出現(xiàn)病理狀態(tài)的乳腺組織,，增加患乳腺癌幾率。
該篇論文的作者表示：女性生育第一個孩子的年齡以及生育孩子的數(shù)量等因素都會干預(yù)乳腺片的密度大小,，影響女性罹患乳腺癌的風險,。(生物谷 Bioon.com)
doi:10.1007/s10549-011-1664-2
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Childhood factors associated with mammographic density in adult women
Virginia Lope, Beatriz Pérez-Gómez, María Pilar Moreno, Carmen Vidal, Dolores Salas-Trejo, Nieves Ascunce, Isabel González Román, Carmen Sánchez-Contador, María Carmen Santamaria and Jose Antonio Vázquez Carrete, et al.
Growth and development factors could contribute to the development of breast cancer associated with an increase in mammographic density. This study examines the influence of certain childhood-related, socio-demographic and anthropometric variables on mammographic density in adult woman. The study covered 3574 women aged 45–68 years, participating in breast cancer-screening programmes in seven Spanish cities. Based on a craniocaudal mammogram, blind, anonymous measurement of mammographic density was made by a single radiologist, using Boyd’s semiquantitative scale. Data associated with the early stages of life were obtained from a direct survey. Ordinal logistic regression and generalised linear models were employed to estimate the association between mammographic density and the variables covered by the questionnaire. Screening programme was introduced as a random effects term. Age, number of children, body mass index (BMI) and other childhood-related variables were used as adjustment variables, and stratified by menopausal status. A total of 811 women (23%) presented mammographic density of over 50%, and 5% of densities exceeded 75%. Our results show a greater prevalence of high mammographic density in women with low prepubertal weight (OR: 1.18; 95% CI: 1.02–1.36); marked prepubertal height (OR: 1.25; 95% CI: 0.97–1.60) and advanced age of their mothers at their birth (>39 years: OR: 1.28; 95% CI: 1.03–1.60); and a lower prevalence of high mammographic density in women with higher prepubertal weight, low birth weight and earlier menarche. The influence of these early-life factors may be explained by greater exposure to hormones and growth factors during the development of the breast gland, when breast tissue would be particularly susceptible to proliferative and carcinogenic stimulus.
