2月14日，澳大利亞研究人員稱,，阿司匹林等非甾體抗炎癥藥物或許能夠抑制癌細胞擴散,，原因是它們有助于切斷輸送這類細胞的“高速公路”。
長期以來,，研究人員推測,，阿司匹林等非甾體抗炎藥可幫助抑制惡性腫瘤擴散，卻沒有能在藥理層面解釋作用機理,。
墨爾本彼得·麥卡勒姆癌癥研究中心研究人員14日說,，“阿司匹林這類藥物的分子……能有效抑制淋巴管擴張，從而削弱腫瘤擴散至身體其他部位的能力”。
在由美國《癌細胞》雜志發(fā)表的論文中,，研究人員解釋,，腫瘤細胞擴散時，淋巴管內(nèi)細胞中一種特定基因改變“表達”,，成為腫瘤生長和細胞輸送的連接點,，可能引發(fā)全身淋巴管炎癥和擴張。淋巴管一旦擴張,，腫瘤細胞經(jīng)由它擴散的能力隨之增強,。
阿司匹林可以抑制淋巴管的擴張，達到切斷腫瘤細胞輸送通道的效果,。
研究人員史蒂芬·施特克爾說：“這就好比,，我們找到了所有助推（癌細胞擴散）因素之間的關(guān)鍵連接點。”
研究人員預(yù)測,，這項發(fā)現(xiàn)可用來研發(fā)新藥,，遏制乳腺癌、前列腺癌等實體惡性腫瘤的擴散,，也可用于在腫瘤細胞擴散前發(fā)出“預(yù)警”,。(生物谷 Bioon.com)
doi:10.1016/j.ccr.2011.12.026
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VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium
Tara Karnezis, Ramin Shayan, Carol Caesar, Sally Roufail, Nicole C. Harris, Kathryn Ardipradja, You Fang Zhang, Steven P. Williams, Rae H. Farnsworth, Ming G. Chai, Thusitha W.T. Rupasinghe, Dedreia L. Tull, Megan E. Baldwin, Erica K. Sloan, Stephen B. Fox, Marc G. Achen, Steven A. Stacker
Lymphatic metastasis is facilitated by lymphangiogenic growth factors VEGF-C and VEGF-D that are secreted by some primary tumors. We identified regulation of PGDH, the key enzyme in prostaglandin catabolism, in endothelial cells of collecting lymphatics, as a key molecular change during VEGF-D-driven tumor spread. The VEGF-D-dependent regulation of the prostaglandin pathway was supported by the finding that collecting lymphatic vessel dilation and subsequent metastasis were affected by nonsteroidal anti-inflammatory drugs (NSAIDs), known inhibitors of prostaglandin synthesis. Our data suggest a control point for cancer metastasis within the collecting lymphatic endothelium, which links VEGF-D/VEGFR-2/VEGFR-3 and the prostaglandin pathways. Collecting lymphatics therefore play an active and important role in metastasis and may provide a therapeutic target to restrict tumor spread.
