(Credit: Image courtesy of Lund University)
耐激素治療和耐放療或化療的前列腺癌需要新的治療方法。近日,，隆德大學(xué)的研究人員開發(fā)出一種新的治療手段——攻擊前列腺癌中具有干細(xì)胞樣特征的細(xì)胞。
斯科訥大學(xué)馬爾默醫(yī)院醫(yī)學(xué)院部的泌尿科癌癥研究教授Rebecka Hellsten高級(jí)研究員和Anders Bjartell教授,，隆德大學(xué)學(xué)院有機(jī)化學(xué)部的助理教授Martin Johansson領(lǐng)導(dǎo)了兩個(gè)研究小組合作開展了這項(xiàng)跨學(xué)科研究項(xiàng)目,，最新研究成果刊登在PLoS ONE雜志上。
Anders Bjartell說(shuō)：“前列腺腫瘤組織中只包含約0.1％的腫瘤干細(xì)胞,，但如果不能成功地消除這些干細(xì)胞,，腫瘤發(fā)展過(guò)程中細(xì)胞生長(zhǎng)仍會(huì)有失控的危險(xiǎn)。腫瘤干細(xì)胞通常對(duì)激素治療和化療反應(yīng)遲鈍（不敏感）,，所以有必要開發(fā)出一種可以對(duì)所有類型的腫瘤細(xì)胞都有作用的治療方法,。”
研究小組通過(guò)研究前列腺癌腫瘤細(xì)胞的生物學(xué)行為發(fā)現(xiàn)，蛋白STAT3對(duì)干細(xì)胞樣前列腺癌細(xì)胞的生物學(xué)功能發(fā)揮重要作用,。研究小組以往的研究已經(jīng)證明,，一種天然化合物——Galiellalactone能影響STAT3，抑制前列腺癌細(xì)胞的生長(zhǎng),。
研究人員希望用Galiellalactone當(dāng)作工具藥,，開發(fā)出新的特異性的STAT3抑制劑，能針對(duì)性地攻擊前列腺癌中干細(xì)胞樣的腫瘤細(xì)胞,，進(jìn)而抑制腫瘤的生長(zhǎng)和擴(kuò)散,。(生物谷 Bioon.com)
doi:10.1371/journal.pone.0022118
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Galiellalactone Inhibits Stem Cell-Like ALDH-Positive Prostate Cancer Cells
Rebecka Hellsten, Martin Johansson, Anna Dahlman, Olov Sterner, Anders Bjartell
Transcriptional coregulators control the activity of many transcription factors and are thought to have wide-ranging effects on gene expression patterns. We show here that muscle-specific loss of nuclear receptor corepressor 1 (NCoR1) in mice leads to enhanced exercise endurance due to an increase of both muscle mass and of mitochondrial number and activity. The activation of selected transcription factors that control muscle function, such as MEF2, PPARβ/, and ERRs, underpins these phenotypic alterations. NCoR1 levels are decreased in conditions that require fat oxidation, resetting transcriptional programs to boost oxidative metabolism. Knockdown of gei-8, the sole C. elegans NCoR homolog, also robustly increased muscle mitochondria and respiration, suggesting conservation of NCoR1 function. Collectively, our data suggest that NCoR1 plays an adaptive role in muscle physiology and that interference with NCoR1 action could be used to improve muscle function.
