母乳的好處是眾所周知的,，但為什么母乳喂養(yǎng)能對(duì)抗各種癌癥仍是一個(gè)謎,。近日，一項(xiàng)發(fā)表在Journal of Human Lactation雜志上的新研究證實(shí)：高水平的具有抗癌作用的腫瘤壞死因子相關(guān)凋亡誘導(dǎo)人奶中配體（TRAIL）可能是母乳抗癌功效的作用機(jī)制,。
研究人員收集初乳,、剛分娩婦女的母乳。然后研究人員獲得健康婦女的血液樣本以及各種嬰幼兒配方奶粉,。測(cè)試所有初乳,、剛分娩婦女的母乳、血液和配方以衡量其中TRAIL的水平,。研究人員發(fā)現(xiàn)相于比血液而言,，初乳和母乳中分別含有400和100倍的TRAIL的高水平。
早期已有文獻(xiàn)證明母乳喂養(yǎng)的對(duì)某些特定的兒童癌癥的預(yù)防非常重要,，如急性淋巴細(xì)胞白血病,、霍奇金病和神經(jīng)母細(xì)胞瘤等。不過(guò),，這項(xiàng)研究證實(shí)內(nèi)源性可溶性TRAIL解釋母乳喂養(yǎng)對(duì)癌癥的整體生物效應(yīng),。
選擇參與該研究的母親均符合研究條件，因?yàn)檫@些母親們沒(méi)有子癇,、感染或發(fā)燒等癥狀,，并能及時(shí)分娩健康新生兒。
作者寫道：據(jù)我們所知,，這是第一次TRAIL在初乳和人類母乳中得到測(cè)試研究,。本研究發(fā)現(xiàn)初乳和母乳中TRAIL的濃度比循環(huán)血清TRAIL的水平高。(生物谷：Bioon.com）
doi:10.1177/0890334412441071
PMC:
PMID:
Human Colostrum and Breast Milk Contain High Levels of TNF-Related Apoptosis-Inducing Ligand (TRAIL)
Riccardo Davanzo,et al.
Background: TNF-related apoptosis inducing ligand (TRAIL) is a pleiotropic cytokine, which plays a key role in the immune system as well as in controlling the balance of apoptosis and proliferation in various organs and tissues.
Objective: To investigate the presence and levels of soluble TRAIL in human colostrum and milk.
Methods: The levels of soluble human TRAIL were measured in human colostrum (day 2 after delivery) and breast milk (day 5 after delivery). The presence of TRAIL was also measured in infant formula.
Results: Levels of soluble TRAIL in the colostrum and mature human milk were, respectively, at least 400 and 100 fold higher than those detected in human serum. No TRAIL was detected in formula.
Conclusion: Human soluble TRAIL is present at extremely high levels in human colostrum and human milk and might have a significant role in mediating the anti-cancer activity of human milk.
