近日，《英國癌癥雜志》（British Journal of Cancer）發(fā)表的一項研究表明,，妊娠高血壓女性罹患乳腺癌的風險降低,，其機制尚不清楚。
該研究納入了一個由1967～2008年間919712例初產(chǎn)婦組成的隊列,，并與兩個英國國家登記處的資料進行關(guān)聯(lián),，進而評估了妊娠高血壓女性的乳腺癌風險是否降低。
結(jié)果顯示,，與妊娠期間血壓正常的初產(chǎn)婦相比,，有妊娠高血壓或先兆子癇的初產(chǎn)婦乳腺癌風險降低[危險比（HR）=0.83，95%可信區(qū)間（CI）=0.77～0.90],。
無論乳腺癌診斷年齡在50歲之前或之后,，任意產(chǎn)次妊娠高血壓和復發(fā)性妊娠高血壓均與乳腺癌風險降低有關(guān)。
在足月產(chǎn)/過期產(chǎn)（HR=0.81,，95%CI=0.75～0.88）或新生兒體重為平均水平（HR=0.77,，95%CI=0.69～0.85）的妊娠高血壓女性中，這種相關(guān)性最強,。（生物谷Bioon.com）
doi:10.1038/bjc.2012.195
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Hypertensive diseases in pregnancy and breast cancer risk
S Opdahl1, P R Romundstad1, M D K Alsaker1,2 and L J Vatten1
Background: Hypertensive diseases in pregnancy may be associated with a reduced risk of breast cancer. Most previous studies are small and have shown conflicting results.
Methods: In a cohort of 919?712 women who gave their first birth between 1967 and 2008, with linkage of information from two national registries, we assessed whether women with pregnancy hypertensive diseases are at reduced breast cancer risk. We used Cox regression to estimate hazard ratios (HRs) with 95% confidence intervals (CI).
Results: Compared with women with a normotensive first pregnancy, women with hypertension or preeclampsia in their first pregnancy had a reduced breast cancer risk (HR 0.83, 95% CI 0.77, 0.90). A reduced risk was consistently observed for hypertensive disease in any pregnancy, for recurrent hypertensive disease in pregnancy, and before and after 50 years of age at breast cancer diagnosis. The association was strongest for women with hypertension in pregnancy, who delivered at term/post-term (HR 0.81, 95% CI 0.75, 0.88) or had a child of average birth weight (HR 0.77, 95% CI 0.69, 0.85).
Conclusion: Women with pregnancy hypertensive diseases are at reduced breast cancer risk. Whether this association can be attributed to pregnancy-specific events or to underlying biological traits remains unclear.
