直到前不久，許多患有I期非小細(xì)胞肺癌(stage I non-small cell lung cancer)的老年患者都未接受過治療,，這是因?yàn)橹委熆赡懿⒉桓纳扑麄兊纳钯|(zhì)量,。然而，立體定向消融放療(stereotactic ablative radiotherapy, SABR)已成為治療這些病人的標(biāo)準(zhǔn)方法之一,。給予為期兩周的門診治療允許體弱的病人接受這種放療。
研究人員想知道這種治療在維持病人健康相關(guān)的生活質(zhì)量方面是否與外科手術(shù)治療的情形相同,。研究人員對在荷蘭68個中心接受SABR治療的382名病人進(jìn)行調(diào)查問卷。這項(xiàng)調(diào)查問卷要求病人對身體功能,、食欲不振、疼痛和情緒功能等方面進(jìn)行評分,。
根據(jù)發(fā)表在國際肺癌研究協(xié)會雜志《胸腔腫瘤期刊》(Journal of Thoracic Oncology) 2012年7月那期上的一項(xiàng)研究,，研究人員作出結(jié)論：就這些病人而言，與健康相關(guān)的生活質(zhì)量似乎并沒受到這種治療的負(fù)面影響,。
研究人員的結(jié)論是,，與接受外科手術(shù)治療的那些病人相比，在接受SABR頭兩年治療后,，包括功能性和癥狀結(jié)果在內(nèi)的生活質(zhì)量指標(biāo)測試分?jǐn)?shù)并沒有發(fā)生惡化,。(生物谷：Bioon.com)
doi:10.1097/JTO.0b013e318219aac5
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Radiological Changes After Stereotactic Radiotherapy for Stage I Lung Cancer
Dahele, Max MBChB, MSc; Palma, David MD; Lagerwaard, Frank MD, PhD; Slotman, Ben MD, PhD; Senan, Suresh FRCR, PhD
Introduction: Stereotactic body radiation therapy (SBRT) is entering routine clinical use for selected patients with early-stage non-small cell lung cancer. Post-SBRT radiological changes are commonly seen on follow-up computed tomography (CT) imaging and can cause diagnostic dilemmas. The aim of this study is to describe the incidence, radiological severity, and long-term morphology of these changes. Methods: CT scans from patients treated between 2003 and June 2008 were eligible for evaluation if radiological follow-up had been performed at our center for at least 2 years, and there was no definite evidence of local recurrence. Timing, incidence, morphology, and severity of lung changes were determined. Results: CT scans from 61 patients (68 lesions) with a median follow-up of 2.5 years were evaluated. Within 6 months, 54% of lesions were associated with additional radiological abnormalities, and this figure reached 99% after 36 months. Most changes were scored as mild to moderate, and although the median time to first observation was 17 weeks, 25% appeared ≥1 year post-SBRT. In 47% of lesions, the morphology or severity of changes continued to evolve more than 2 years posttreatment. Conclusions: Mild-moderate radiological changes are common after lung SBRT. Some degree of late change is nearly universal, and it often continues to evolve more than 2 years post-SBRT. Clinicians should be aware of these radiological findings, which need to be distinguished from the uncommon cases of local failure post-SBRT.
