早期生活陷入親子關(guān)系困境的人在過去一年有嚴(yán)重生活困擾的話可能會罹患一種最常見的皮膚癌——基底細(xì)胞癌（BCC）。這項(xiàng)研究發(fā)表在Archives of General Psychiatry雜志上,。
文章背景資料指出,，壓力事件和由此產(chǎn)生的負(fù)面情緒可以引發(fā)人體的免疫系統(tǒng)功能障礙，帶來臨床癥狀的重大變化,，影響基底細(xì)胞癌以及病情的發(fā)展,。童年暴曬于太陽下，白皙的皮膚類型和男性性別是基底細(xì)胞癌的第一危險(xiǎn)因素,，但研究人員強(qiáng)調(diào)但其該類型實(shí)腫瘤不只與這些危險(xiǎn)因素有關(guān),。
基底細(xì)胞癌患者體內(nèi)免疫系統(tǒng)對腫瘤細(xì)胞起著負(fù)面突出作用，因?yàn)槟[瘤細(xì)胞具有免疫原性,，基底細(xì)胞癌不像其他許多常見的癌癥,，不會表現(xiàn)出同樣的免疫系統(tǒng)反應(yīng)，同時(shí)研究還發(fā)現(xiàn)患者心里壓力可能對腫瘤的發(fā)生發(fā)展也發(fā)揮重要作用,。
哥倫布俄亥俄州州立大學(xué)醫(yī)學(xué)中心Christopher P. Fagundes博士他的團(tuán)隊(duì)考察了48男和43女,，年齡在23歲至92歲之間的人，這些人早期都患有基底細(xì)胞癌,，研究人員評估了這些人及其子女的最近生活狀況,、抑郁癥和mRNA（信使RNA）的情況。
我們的研究結(jié)果表明基底細(xì)胞癌患者在過去一年中經(jīng)歷了嚴(yán)重的應(yīng)激,，那些經(jīng)歷母親或父親的情感虐待的孩子更可能有較差的免疫反應(yīng),，表現(xiàn)為CD2 5、CD3ε,、ICAM-1和CD68的mRNA的表達(dá)水平較低,。研究人員得出結(jié)論：我們的研究數(shù)據(jù)顯示基底細(xì)胞癌的風(fēng)險(xiǎn)與早期生活壓力有關(guān)。（生物谷：Bioon.com）
doi:10.1001/archgenpsychiatry.2011.1535
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Basal Cell CarcinomaStressful Life Events and the Tumor Environment
Christopher P. Fagundes, PhD; Ronald Glaser, PhD; Sheri L. Johnson, PhD; Rebecca R. Andridge, PhD; Eric V. Yang, PhD; Michael P. Di Gregorio, MS; Min Chen, MS; David R. Lambert, MD; Scott D. Jewell, MD; Mark A. Bechtel, MD; Dean W. Hearne, MD; Joel B. Herron, MD; Janice K. Kiecolt-Glaser, PhD
Context Child emotional maltreatment can result in lasting immune dysregulation that may be heightened in the context of more recent life stress. Basal cell carcinoma (BCC) is the most common skin cancer, and the immune system plays a prominent role in tumor appearance and progression.
Objective To address associations among recent severe life events, childhood parental emotional maltreatment, depression, and messenger RNA (mRNA) coding for immune markers associated with BCC tumor progression and regression.
Design We collected information about early parent-child experiences, severe life events in the past year as assessed by the Life Events and Difficulties Schedule, depression, and mRNA for immune markers associated with BCC tumor progression and regression from patients with BCC tumors.
Setting University medical center.
Participants Ninety-one patients with BCC (ages, 23-92 years) who had a previous BCC tumor.
Main Outcome Measures The expression of 4 BCC tumor mRNA markers (CD25, CD3ϵ, intercellular adhesion molecule 1, and CD68) that have been linked to BCC tumor progression and regression were assessed in BCC tumor biopsy specimens.
Results Both maternal and paternal emotional maltreatment interacted with the occurrence of severe life events to predict the local immune response to the tumor (adjusted P = .009 and P = .03, respectively). Among BCC patients who had experienced a severe life event within the past year, those who were emotionally maltreated by their mothers (P = .007) or fathers (P = .02) as children had a poorer immune response to the BCC tumor. Emotional maltreatment was unrelated to BCC immune responses among those who did not experience a severe life event. Depressive symptoms were not associated with the local tumor immune response.
Conclusions Troubled early parent-child relationships, in combination with a severe life event in the past year, predicted immune responses to a BCC tumor. The immunoreactivity observed in BCCs and the surrounding stroma reflects an anti–tumor-specific immune response that can be altered by stress.
