近日,，加拿大研究人員在美國新一期《國家科學(xué)院院刊》（PNAS）上報告說,，動物實驗顯示，一種超聲波療法能讓腫瘤對放射性治療更加敏感,。
放療主要通過破壞DNA及腫瘤血管來摧毀腫瘤,。微泡在超聲激發(fā)的情況下，可以破壞病理結(jié)構(gòu)薄弱的腫瘤新生血管,。
研究人員通過靜脈向?qū)嶒炇笕橄倌[瘤部位注射了微泡，然后讓該區(qū)域接觸能使微泡破裂的超聲波頻率,，部分腫瘤隨后又接受了放療,。結(jié)果發(fā)現(xiàn)，這種組合治療造成的腫瘤細(xì)胞死亡數(shù)比單獨使用放療要多出約10倍,，相對于只使用放療,，組合療法重復(fù)治療能延長實驗鼠的存活時間，并延緩腫瘤的生長,。研究人員所用的微泡是微米直徑的惰性氣體球,。
研究人員表示，放療輔以超聲波激發(fā)的微泡可能會增加癌癥療法的功效,，并減少所需放療的總劑量,。（生物谷Bioon.com）
doi:10.1073/pnas.1200053109
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Tumor radiation response enhancement by acoustical stimulation of the vasculature
Gregory J. Czarnotaa,b,c,d,1, Raffi Karshafianc,d,e, Peter N. Burnsc,d, Shun Wonga,b,d, Azza Al Mahroukia,c, Justin W. Leea,b,c,d, Amanda Caissiea,c, William Trana, Christina Kima,c,d, Melissa Furukawaa,c, Emily Wonga,c, and Anoja Gilesa,c
We have discovered that ultrasound-mediated microbubble vascular disruption can enhance tumor responses to radiation in vivo. We demonstrate this effect using a human PC3 prostate cancer xenograft model. Results indicate a synergistic effect in vivo with combined single treatments of ultrasound-stimulated microbubble vascular perturbation and radiation inducing an over 10-fold greater cell kill with combined treatments. We further demonstrate with experiments in vivo that induction of ceramide-related endothelial cell apoptosis, leading to vascular disruption, is a causative mechanism. In vivo experiments with ultrasound and bubbles permit radiation doses to be decreased significantly for comparable effect. We envisage this unique combined ultrasound-based vascular perturbation and radiation treatment method being used to enhance the effects of radiation in a tumor, leading to greater tumor eradication.
