腎癌可能影響大約1%的總?cè)丝凇Ｖ暗拇蠖鄶?shù)流行病學(xué)研究已表明適量飲酒與較低風(fēng)險(xiǎn)患上腎癌相關(guān)聯(lián),。在已經(jīng)發(fā)布的前瞻性群體研究(prospective cohort study)中,，在適量飲酒的人們當(dāng)中患上腎癌的風(fēng)險(xiǎn)通常要比不飲酒的人們降低大約25%,。
這項(xiàng)比較好的整合分析支持如下發(fā)現(xiàn)：相對于更加可靠的前瞻性群體研究而言,，當(dāng)前發(fā)表在British Journal of Cancer 期刊的新研究發(fā)現(xiàn)相對于飲酒最少的實(shí)驗(yàn)參與者，飲酒最多的參與者患上腎癌的風(fēng)險(xiǎn)下降29%,。
這些發(fā)現(xiàn)提示著不論是男人還是女人,，也不論哪種類型的酒精飲料，都存在類似的影響,。
不過需要注意的是,，這種影響在參與者每天喝一杯酒的水平上觀察到的,，喝更多的酒不會(huì)導(dǎo)致患腎癌的風(fēng)險(xiǎn)進(jìn)一步降低。(生物谷：Bioon.com)
本文編譯自Moderate alcohol intake is associated with a lower risk of kidney cancer
doi: 10.1038/bjc.2012.136
PMC:
PMID:
Alcohol intake and renal cell cancer risk: a meta-analysis
D Y Song, S Song, Y Song and J E Lee
Background: An inverse association between alcoholic beverage intake and risk of renal cell cancer has been suggested in recent studies. Methods: We examined the association between alcoholic beverages and renal cell cancer risk in a meta-analysis. We identified relevant studies by searching the database of PubMed, EMBASE, and MEDLINE published through August 2011. We combined the study-specific relative risks (RRs) using a random-effects model. Results: A total of 20 case–control studies, 3 cohort studies, and 1 pooled analysis of cohort studies were included in the meta-analysis. We observed that alcoholic beverage intake was associated with a lower risk of renal cell cancer in combined analysis of case–control and cohort studies; for total alcoholic beverage intake, combined RRs (95% confidence intervals) comparing top with bottom categories were 0.76 (0.68–0.85) in case–control studies, and 0.71 (0.63–0.78) in cohort studies (P for difference by study design=0.02). The inverse associations were observed for both men and women and for each specific type alcoholic beverage (beer, wine, and liquor). Also, we found that one drink per day of alcoholic beverage conferred the reduction in renal cell cancer risk, but further drinking above that level did not add benefit. Conclusion: The findings from our meta-analysis support the hypothesis that alcoholic beverage intake is inversely associated with a lower risk of renal cell cancer, with moderate consumption conferring the protection and higher consumption conferring no additional benefits.
