使用熱瀝青(hot asphalt )的屋頂建筑工和道路建設(shè)工暴露在高水平多環(huán)芳香烴(polycyclic aromatic hydrocarbons, PAHs)之中。根據(jù)發(fā)表在British Medical Journal Open期刊上的一篇論文,，來自美國科羅拉多大學(xué)癌癥中心的研究人員發(fā)現(xiàn),，在換班之后，屋頂建筑工血液含有更高水平的PAH,，而且這些高水平PAH與增加的DNA損傷率相關(guān)聯(lián),，從而潛在地與更高風(fēng)險患上癌癥相關(guān)聯(lián)。
研究人員早就知道屋頂建筑工和道路建設(shè)工癌癥發(fā)病率比一般人高,，而且屋頂建筑工吸煙喝酒比例和紫外線照射量也比一般人高,，因此很難準確地找出導(dǎo)致更高癌癥發(fā)病率的原因：是更高水平的PAH或者是生活方式和其他風(fēng)險因子？
論文通信作者和她的同事們研究了來自美國邁阿密戴德縣4個工作場所的19名屋頂建筑工,。他們分析了這19名研究參與者換班前6小時和換班后6小時的尿液樣品,，發(fā)現(xiàn)在短時間嚴重暴露在熱瀝青之中，PAH生物標記物水平升高,?？傮w而言，在沒有帶上保護手套的那些工人和存在工作相關(guān)的皮膚燒傷的那些工人當中,，PAH生物標記物水平和氧化性DNA損傷(8-OHdG)是最高的,，從而表明PAH通過皮膚吸收而發(fā)揮作用。
Serdar和同事們對丹佛大城市區(qū)域的屋頂建筑工啟動一項更廣泛的研究,，這項研究將同時研究空氣,、血液和尿液中的PAHs水平，以及與來自他們的樣品中DNA損傷之間的聯(lián)系,。(生物谷：Bioon.com)
本文編譯自DNA damage in roofers due to PAH exposure -- possible cancer link
doi: 10.1136/bmjopen-2012-001318
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Biomarkers of exposure to polycyclic aromatic hydrocarbons (PAHs) and DNA damage: a cross-sectional pilot study among roofers in South Florida
Berrin Serdar1,2, David Lee3, Zihong Dou4
Objective The main goal of this pilot study was to assess the technical and logistic feasibility of a future study. The research hypothesis is that occupational exposures to polycyclic aromatic hydrocarbons (PAHs) are associated with increased risk of DNA damage among roofers who work with hot asphalt. Design This is a cross-sectional pilot study. Setting The study included roofers from four different construction sites in Miami-Dade County, Florida. Participants 19 roofers were recruited (six Hispanics and 13 African–Americans, all male), all of whom were eligible (no history of cancer and no history of chronic diseases of kidneys or liver). All participants provided pre-shift samples and 18 provided post-shift samples. Samples of one participant were excluded from the final analyses as they were considered unreliable. Results Levels of urinary PAH metabolites increased during 6 h of work. Linear regression models of post-shift metabolites included their pre-shift levels, post-shift urinary creatinine levels (for models of 1-OHPyr and 9-OHPhe), and skin burn due to contact with hot asphalt (for models of 1-OHPyr and 1-OHNap). Pre-shift levels of urinary 8-OHdG were not associated with any of the variables considered. For post-shift levels of 8-OHdG, however, post-shift 1-OHPyr (95% CI 0.091 to 0.788) and use of protective gloves (95% CI −1.57 to −0.61) during work explained 86.8% of its variation. Overall, highest levels of urinary PAH metabolites and of 8-OHdG were observed among workers who reported having skin burn and who did not use gloves during work. Conclusions Urinary 1-OHPyr is a promising predictor of oxidative DNA damage among roofers. Work-related skin burn and use of protective gloves appear to influence PAH exposure and DNA damage levels in this group, suggesting the importance of dermal absorption.
