據(jù)一項(xiàng)發(fā)表在Cancer Research雜志上的最新研究證實(shí)，蛋白質(zhì)瞬時(shí)感受器電位m7通道（TRPM7）是乳腺癌細(xì)胞轉(zhuǎn)移的一個(gè)關(guān)鍵因子,。研究發(fā)現(xiàn),，至少在乳腺癌轉(zhuǎn)移異種移植模型中，TRPM7對(duì)轉(zhuǎn)移是必須的,，雖然這個(gè)發(fā)現(xiàn)不會(huì)有直接影響對(duì)病人的治療,，但他們相信這項(xiàng)新發(fā)現(xiàn)為癌癥治療開辟了新思路。
腫瘤轉(zhuǎn)移的關(guān)鍵是原腫瘤部位腫瘤細(xì)胞粘附和遷移能力的變化,。而TRPM7被證實(shí)參與調(diào)節(jié)細(xì)胞粘附和遷移過(guò)程,，荷蘭阿姆斯特丹癌癥研究所的研究人員著手調(diào)查是否TRMP7能促進(jìn)癌細(xì)胞轉(zhuǎn)移。
他們?cè)u(píng)估TRPM7的基因表達(dá)水平是否與乳腺癌的進(jìn)展密切相關(guān),。從診斷患有原發(fā)性乳腺腫瘤368名婦女得到的腫瘤組織發(fā)現(xiàn)TRPM7基因高表達(dá)水平與疾病的復(fù)發(fā)和遠(yuǎn)處轉(zhuǎn)移發(fā)生顯著相關(guān),。
研究能夠證明TRPM7高表達(dá)水平是這些婦女患者預(yù)后的獨(dú)立預(yù)測(cè)，但這是否能用于預(yù)測(cè)病人的預(yù)后有待進(jìn)一步驗(yàn)證,。該項(xiàng)研究結(jié)果表明,，抑制TRPM7能導(dǎo)致乳腺癌細(xì)胞體外遷移能力下降，小鼠體內(nèi)轉(zhuǎn)移潛能亦降低,。
研究人員工作假設(shè)是,，TRPM7在乳腺癌細(xì)胞和它們環(huán)境之間的相互作用中有關(guān)鍵作用。乳腺癌細(xì)胞對(duì)環(huán)境因素非常敏感,?？蒲腥藛T認(rèn)為，但尚未有沒(méi)有證明TRPM7通道傳感器促使乳腺癌細(xì)胞能更加感知環(huán)境的變化,。（生物谷：Bioon.com）
編譯自：TRPM7 Protein Key to Breast Cancer Metastasis in Animal Models
doi:10.1158/0008-5472.CAN-11-3863
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PMID:
TRPM7 Is Required for Breast Tumor Cell Metastasis.
Jeroen Middelbeek, Arthur J. Kuipers, Linda Henneman, Daan Visser, Ilse Eidhof, Remco van Horssen, Bé Wieringa, Sander V. Canisius, Wilbert Zwart, Lodewyk F. Wessels, Fred C.G.J. Sweep, Peter Bult, Paul N. Span, Frank N. van Leeuwen, and Kees Jalink.
TRPM7 encodes a Ca2+-permeable nonselective cation channel with kinase activity. TRPM7 has been implicated in control of cell adhesion and migration, but whether TRPM7 activity contributes to cancer progression has not been established. Here we report that high levels of TRPM7 expression independently predict poor outcome in breast cancer patients and that it is functionally required for metastasis formation in a mouse xenograft model of human breast cancer. Mechanistic investigation revealed that TRPM7 regulated myosin II–based cellular tension, thereby modifying focal adhesion number, cell–cell adhesion and polarized cell movement. Our findings therefore suggest that TRPM7 is part of a mechanosensory complex adopted by cancer cells to drive metastasis formation.
