2012年8月30日 訊 /生物谷BIOON/ --華盛頓州立大學(xué)研究人員發(fā)現(xiàn)了滴蟲引發(fā)前列腺癌的機(jī)制,，這項(xiàng)最新研究成果可能有助于開發(fā)更好的診斷和治療方法,。研究人員已經(jīng)發(fā)現(xiàn)男性患滴蟲病是如何患上前列腺癌的機(jī)制,，滴蟲病是一種可治愈的,，但常常被忽視的性傳播疾病,。早期研究已經(jīng)提示兩種疾病之間的相關(guān)性,，但這項(xiàng)最新的研究提出更具體的生物機(jī)制,。華盛頓州立大學(xué)分子生物科學(xué)學(xué)院教授John Alderete說,，滴蟲寄生激活了一整套蛋白質(zhì),，這使得蛋白質(zhì)保持活躍。這就像開啟電燈開關(guān)一樣,，如果你不控制光線的亮度,，你將會(huì)失明。
Alderete和美國(guó)華盛頓州立大學(xué)和華盛頓大學(xué)圣路易斯分校的同事在PLoS Pathogens雜志上發(fā)表了這項(xiàng)最新研究成果,。毛滴蟲病由原生動(dòng)物寄生蟲引起,，通常被稱為是最常見的可治愈的性傳播感染。然而,，大多數(shù)感染者病沒有任何癥狀,，因此常常不會(huì)接受治療。
Alderete說：大多數(shù)女性是這種性傳播感染疾病的首要感人人群,，今年至少有10萬婦女感染以及同等數(shù)量的男性感染此類疾病,。受感染的婦女有妊娠并發(fā)癥及感染艾滋病病毒的風(fēng)險(xiǎn)更大。受感染的男性有40％的機(jī)會(huì)會(huì)罹患前列腺癌,。華盛頓州立大學(xué)癌癥研究人員Nancy Magnuson對(duì)于癌細(xì)胞生長(zhǎng)的啟動(dòng)蛋白質(zhì)PIM1是一位專家,，相關(guān)研究人員確定了該蛋白調(diào)控的級(jí)聯(lián)蛋白質(zhì)是如何導(dǎo)致滴蟲性感染疾病發(fā)展成為前列腺癌的分子機(jī)制。 （生物谷：Biooon.com）
doi:10.1371/journal.ppat.1002801
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Trichomonosis, a Common Curable STI, and Prostate Carcinogenesis—A Proposed Molecular Mechanism
Siobhan Sutcliffe1, Calvin Neace2, Nancy S. Magnuson2, Raymond Reeves2, J. F. Alderete2*
Trichomonosis, a sexually transmitted infection (STI) caused by the protist Trichomonas vaginalis, has significant public health relevance. The annual incidence is ~8 million women in the United States and 170 million worldwide, with an equal number of infected male partners [1]. Both men and women infected with T. vaginalis are at increased risk for human immunodeficiency virus infection [1]. Recent evidence suggests this STI is associated with increased risk of prostate cancer, the most commonly diagnosed cancer and the second leading cause of cancer death among men in the United States [2]. There is no immunity to T. vaginalis, and a hallmark of this STI agent is persistence. Most T. vaginalis infections in men are asymptomatic, and few are diagnosed and treated; thus, infections persist. In older, pre-antibiotic era studies, T. vaginalis was frequently found in prostate fluid specimens from asymptomatic male partners of women with trichomonosis, leading to the belief that the prostate might serve as the reservoir for trichomonosis in men [3]. Trichomonosis may cause chronic prostatitis, and researchers have identified trichomonads in the prostatic urethra, glandular lumina, submucosa, and stroma [4] and, more recently, in benign hyperplastic prostatic tissue [3]. They also observed foci of nonspecific acute and chronic inflammation, as well as intraepithelial vacuolization, near trichomonads, leading them to propose that trichomonosis might contribute to prostate carcinogenesis [4].
