2012年9月10日 訊 /生物谷BIOON/ --近日，來自南加利福尼亞大學(xué)（USC）的研究者發(fā)現(xiàn)了大麻使用和患特定類型睪丸癌之間的關(guān)系，相關(guān)研究成果刊登在了近日的國際雜志Cancer上。文章中，研究者描述了大麻對于睪丸細胞潛在的癌癥誘發(fā)效應(yīng)。
睪丸癌是15至45歲男性常見的一種癌癥，而且其是越來越常見的一種惡性腫瘤,。因此研究者試圖去研究其與患者暴露的環(huán)境是否有某種潛在的關(guān)系。為了觀察大麻的使用是否是睪丸癌誘發(fā)的一個因素,，研究者分析了163位被診斷為睪丸癌患者的信息以及將這些患者與292名相同年齡的健康男性進行對比,。通過研究發(fā)現(xiàn)，接觸大麻的男性相比不接觸的男性,，其患特定類型的睪丸癌（非精原細胞瘤和混合生殖細胞瘤）的風(fēng)險是后者的2倍以上,。
研究者Cortessis說道，我們并不知道大麻中什么成分可以促使睪丸發(fā)生癌變,，我們推測可能是由于內(nèi)源性大麻素所導(dǎo)致的,。研究者同時也發(fā)現(xiàn)了有可卡因使用歷史的男性其患特定類型的睪丸癌的風(fēng)險反而降低了，但是可卡因如何降低患癌風(fēng)險就不得而知了,。（生物谷Bioon.com）
編譯自：Marijuana Use May Increase Risk of Testicular Cancer
doi:10.1002/cncr.27554
PMC:
PMID:
Population-based case-control study of recreational drug use and testis cancer risk confirms an association between marijuana use and nonseminoma risk
John Charles A. Lacson MS1, Joshua D. Carroll BA1,2, Ellenie Tuazon MPH1, Esteban J. Castelao MD, PhD1,3, Leslie Bernstein PhD4, Victoria K. Cortessis MSPH, PhD1,‡,*
BACKGROUND: Testicular germ cell tumor (TGCT) incidence increased steadily in recent decades, but causes remain elusive. Germ cell function may be influenced by cannabinoids, and 2 prior epidemiologic studies reported that the use of marijuana may be associated with nonseminomatous TGCT. Here, the authors evaluate the relation between TGCTs and exposure to marijuana and other recreational drugs using a population-based case-control study.
METHODS: In total, 163 patients who were diagnosed with TGCT in Los Angeles County from December 1986 to April 1991 were enrolled, and 292 controls were matched on age, race/ethnicity, and neighborhood. Participants were asked about drug use by a structured, in-person interview. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression analysis adjusted for history of cryptorchidism; education; religiosity; and reported use of marijuana, cocaine, and amyl nitrite.
RESULTS: Compared with never use, ever use of marijuana had a 2-fold increased risk (OR, 1.94; 95% CI, 1.02-3.68), whereas ever use of cocaine had a negative association with TGCT (OR, 0.54; 95% CI, 0.32-0.91). Stratification on tumor histology revealed a specific association of marijuana use with nonseminoma and mixed histology tumors (OR, 2.42; 95% CI, 1.08-5.42).
CONCLUSIONS: A specific association was observed between marijuana use and the risk of nonseminoma and mixed tumors. To the authors' knowledge, this is the first report of a negative association between cocaine use and TGCT risk. The current results warrant mechanistic studies of marijuana's effect on the endocannabinoid system and TGCT risk and caution that recreational and therapeutic use of cannabinoids by young men may confer malignant potential to testicular germ cells. Cancer 2012. © 2012 American Cancer Society.
