生物谷報道：現(xiàn)代的生物信息學(xué)技術(shù)已經(jīng)使人類更清晰認(rèn)識到生命的機(jī)制,。最新一期PNAS報道了中國臺灣學(xué)者李文雄（音譯）最新研究成果,，采用統(tǒng)計學(xué)方法成功鑒定出酵母的細(xì)胞周期中的轉(zhuǎn)錄因子網(wǎng)絡(luò)。通過生物信息學(xué)手段成功預(yù)測了50個酵母細(xì)胞周期轉(zhuǎn)錄因子之間相互作用的規(guī)律,。這一研究成果將為生物信息學(xué)在生命科學(xué)領(lǐng)域中的更深入應(yīng)用提供更廣泛的基礎(chǔ)的,。
生物信息學(xué)的應(yīng)用解決了傳統(tǒng)的生物學(xué)方法所不能解決的生命網(wǎng)絡(luò)和系統(tǒng)生物學(xué)等問題。
專欄：系統(tǒng)生物學(xué)進(jìn)展
Fig. 1. The regulatory behaviors of 50 known or putative yeast cell cycle TFs. The descriptions are from Tables 1, 2, 3, 4 and 9 and the literature. TF in red (blue) means that genes in G are expressed significantly higher (lower) than genes in G-. TF in black means that, although it is not identified by the first method (detection of individual TFs), it is detected by the second method (detection of synergistic pairs). A TF filled with green means a known cell cycle TF, yellow means highly confident, and gray means plausible. An edge connecting two TFs implies that the two TFs are synergistic according to our analysis. An edge (,) in red (blue) means that TFs and have positive (negative) synergy; plausible pairs are in thin lines, and highly confident pairs are in thick lines. A synergistic pair in green means supported by literature, and a synergistic pair in yellow means consistent with predictions of other studies.
