BMP-7最初是作為一種骨誘導(dǎo)劑（bone inducer）被發(fā)現(xiàn)的,，但它還有很強的腎再生和神經(jīng)再生效應(yīng),。
現(xiàn)在，研究人員報告它能通過促進(jìn)棕色（而不是白色）脂肪細(xì)胞的分化來調(diào)控體內(nèi)能量平衡,。BMP-7能夠打開棕色脂肪的調(diào)控因子,，包括PRDM16（見/biology/integrated/373602.shtml）和成脂肪轉(zhuǎn)錄因子，并且刺激線粒體的生物生成,。BMP-7在小鼠體內(nèi)的異位表達(dá)能增加棕色（而不是白色）脂肪質(zhì),，導(dǎo)致能量消耗增多和體重增加減慢。這些結(jié)果對于肥胖癥的治療顯然有參考價值,。(生物谷Bioon.com）
生物谷推薦原始出處：
Nature 454, 1000-1004 (21 August 2008) | doi:10.1038/nature07221
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
Yu-Hua Tseng1, Efi Kokkotou3, Tim J. Schulz1, Tian Lian Huang1, Jonathon N. Winnay1, Cullen M. Taniguchi1, Thien T. Tran1, Ryo Suzuki1, Daniel O. Espinoza1, Yuji Yamamoto1, Molly J. Ahrens4, Andrew T. Dudley4, Andrew W. Norris5, Rohit N. Kulkarni2 & C. Ronald Kahn1
Section on Obesity and Hormone Action, and,
Section on Cell and Molecular Physiology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, 02215, USA
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02215, USA
Department of Biochemistry, Northwestern University, Evanston, Illinois 60208, USA
Division of Pediatric Endocrinology, University of Iowa Children's Hospital, Iowa City, Iowa 52242, USA
Adipose tissue is central to the regulation of energy balance. Two functionally different types of fat are present in mammals: white adipose tissue, the primary site of triglyceride storage, and brown adipose tissue, which is specialized in energy expenditure and can counteract obesity1. Factors that specify the developmental fate and function of white and brown adipose tissue remain poorly understood2, 3. Here we demonstrate that whereas some members of the family of bone morphogenetic proteins (BMPs) support white adipocyte differentiation, BMP7 singularly promotes differentiation of brown preadipocytes even in the absence of the normally required hormonal induction cocktail. BMP7 activates a full program of brown adipogenesis including induction of early regulators of brown fat fate PRDM16 (PR-domain-containing 16; ref. 4) and PGC-1 (peroxisome proliferator-activated receptor- (PPAR) coactivator-1; ref. 5), increased expression of the brown-fat-defining marker uncoupling protein 1 (UCP1) and adipogenic transcription factors PPAR and CCAAT/enhancer-binding proteins (C/EBPs), and induction of mitochondrial biogenesis via p38 mitogen-activated protein (MAP) kinase-(also known as Mapk14) and PGC-1-dependent pathways. Moreover, BMP7 triggers commitment of mesenchymal progenitor cells to a brown adipocyte lineage, and implantation of these cells into nude mice results in development of adipose tissue containing mostly brown adipocytes. Bmp7 knockout embryos show a marked paucity of brown fat and an almost complete absence of UCP1. Adenoviral-mediated expression of BMP7 in mice results in a significant increase in brown, but not white, fat mass and leads to an increase in energy expenditure and a reduction in weight gain. These data reveal an important role of BMP7 in promoting brown adipocyte differentiation and thermogenesis in vivo and in vitro, and provide a potential new therapeutic approach for the treatment of obesity
