據(jù)10月9日的《科學》雜志報道說,，承蒙多巴胺受體基因之惠，腦子對某一可口奶昔的反應(yīng)可以幫助解釋為什么有些人會體重增加,，而其他人則能維持瘦的狀態(tài),。
在對年輕女性進行的某一新的研究中，一種特別的多巴胺D2 受體基因可以幫助研究人員預(yù)測在第一次品嘗測試實驗之后長達一年的時間內(nèi)體重的增長情況,。腦子的背側(cè)紋狀體會釋放神經(jīng)遞質(zhì)多巴胺以作為對進食所做出的反應(yīng),，而多巴胺釋放量與食物所帶來的快感程度相對應(yīng)。但是在肥胖的人中,，這一多巴胺反應(yīng)由于其體內(nèi)多巴胺受體較少而似乎變得遲緩,，也許由此而導(dǎo)致人們過多地進食以彌補快感的下降。
Eric Stice 及其同僚應(yīng)用腦成像技術(shù)觀察女性對巧克力奶昔或一種模擬唾液的“無味道溶液”的反應(yīng),。在品嘗測試期間,，肥胖者的背側(cè)紋狀態(tài)較不活躍，而攜帶A1 型紋狀體多巴胺D2 受體基因者對奶昔的反應(yīng)最為遲鈍,。研究人員發(fā)現(xiàn),，帶有A1 基因的婦女同時也最有可能在緊接著的一年時間中體重有所增加。（生物谷Bioon.com）
在響應(yīng)巧克力奶昔相對與無味時,，該大腦圖表顯示BMI與背紋狀體內(nèi)較弱激活相關(guān),。
生物谷推薦原始出處：
Science 17 October 2008: 449-452.
Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele
E. Stice, S. Spoor, C. Bohon, and D. M. Small
The dorsal striatum plays a role in consummatory food reward, and striatal dopamine receptors are reduced in obese individuals, relative to lean individuals, which suggests that the striatum and dopaminergic signaling in the striatum may contribute to the development of obesity. Thus, we tested whether striatal activation in response to food intake is related to current and future increases in body mass and whether these relations are moderated by the presence of the A1 allele of the TaqIA restriction fragment length polymorphism, which is associated with dopamine D2 receptor (DRD2) gene binding in the striatum and compromised striatal dopamine signaling. Cross-sectional and prospective data from two functional magnetic resonance imaging studies support these hypotheses, which implies thatindividuals may overeat to compensate for a hypofunctioning dorsal striatum, particularly those with genetic polymorphisms thought to attenuate dopamine signaling in this region.
