據(jù)11月6日的《科學(xué)》雜志報(bào)道說,，一項(xiàng)新的研究表明,，燃燒油脂可以使壽命延長,，至少在蠕蟲中是如此,。Meng Wang及其同僚說，在C. elegans （或譯：秀麗小桿線蟲）中,，當(dāng)該蠕蟲的生殖干細(xì)胞停止增生之后,，一種可以燃燒油脂的酶的活性會增加,，結(jié)果是其壽命得以延長。
Ting Xie在一則有關(guān)的Perspective 中提出,，他們的發(fā)現(xiàn)對代謝調(diào)節(jié)、壽命和生殖是如何互相糾纏的機(jī)制提供了一個進(jìn)一步激發(fā)人們興趣的一瞥,。Wang及其同僚顯示，成年蠕蟲的生殖干細(xì)胞會活躍地控制脂酶K04A8.5的水平,，而這種酶會減少腸脂的水平,。當(dāng)干細(xì)胞停止增生的時候，脂酶的水平顯著上升并開始消耗油脂,。研究人員發(fā)現(xiàn),，那些腸脂酶被激活的蠕蟲的壽命比其同屬的蠕蟲增加了24%,。（生物谷Bioon.com）
生物谷推薦原始出處：
Science 7 November 2008:Vol. 322. no. 5903, pp. 957 - 960 DOI: 10.1126/science.1162011
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
Meng C. Wang, Eyleen J. O'Rourke, Gary Ruvkun
Fat metabolism, reproduction, and aging are intertwined regulatory axes; however, the mechanism by which they are coupled remains poorly understood. We found that germline stem cells (GSCs) actively modulate lipid hydrolysis inCaenorhabditis elegans, which in turn regulates longevity. GSC arrest promotes systemic lipolysis via induction of a specific fat lipase. Subsequently, fat mobilization is promoted and life span is prolonged. Constitutive expression of this lipase in fat storage tissue generates lean and long-lived animals. This lipase is a key factor in the lipidhydrolysis and increased longevity that are induced by decreased insulin signaling. These results suggest a link between C. elegans fat metabolism and longevity.
Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
