許多最新的研究表明,，衰老以及同衰老相關(guān)的疾病與不可控的炎癥反應(yīng)有關(guān)。韓國釜山國立大學(xué)藥學(xué)院Jae Heun Chung等人通過對過氧化物酶體增殖物激活受體（PPAR）研究認(rèn)為,，在衰老過程中,，核受體亞家族轉(zhuǎn)錄因子的減少，過氧化物酶體增殖物激活受體的活化同炎癥抑制水平的提高有很密切的關(guān)系,，PPAR在體內(nèi)和體外的抗炎癥反應(yīng)都說明了PPARs在炎癥疾病發(fā)病機(jī)制中起著很重要的作用,。PPAR屬于由配體激活的Ⅱ型核受體超家族成員，有三種異構(gòu)形式,，即α,、β和γ型,，廣泛分布于人體,，主要分布于肝臟、腎臟,、褐色脂肪組織,。
Devchand等發(fā)現(xiàn)了白三烯B4是PPARα的配體，PPARα的激活可導(dǎo)致白三烯B4分解,，限制炎癥反應(yīng)因此,，PPAR的激活對動脈粥樣硬化的并發(fā)癥如心肌梗死和斑塊破裂具有保護(hù)作用。
不僅如此,，PPARs的活化還可以改善包括糖尿病,、高血壓和肥胖等在內(nèi)的胰島素抵抗綜合征，而且還直接作用于血管壁,，從而減緩動脈粥樣硬化的進(jìn)程,。深入的研究PPAR受體陪體的分子機(jī)制，將為我們開啟治療動脈粥樣硬化,、血管性疾病,、阿爾茨海默癥和癌癥等頑疾的大門。相關(guān)文章發(fā)表在愛思唯爾期刊《衰老研究評論》（Ageing Research Reviews）上,。（生物谷Bioon.com）
生物谷推薦原始出處：
Ageing Research Reviews,，Volume 7, Issue 2, April 2008, Pages 126-136，Jae Heun Chung,，Hae Young Chung
Molecular mechanism of PPAR in the regulation of age-related inflammation
Jae Heun Chunga, Arnold Y. Seob, Sang Woon Chunga, Mi Kyung Kimc, Christiaan Leeuwenburghb, Byung Pal Yud and Hae Young Chunga, b, ,
aDepartment of Pharmacy, College of Pharmacy, Pusan National University, San 30, Jang-jun-dong, Geomjung-ku, Busan 609-735, South Korea
bDepartment of Aging and Geriatrics, College of Medicine, Institute on Aging, Biochemistry of Aging Laboratory, University of Florida, Gainesville, FL 36210-0107, USA
cLongevity Life Science & Technology Institutes, Pusan National University, San 30, Jang-jun-dong, Geomjung-ku, Busan 609-735, South Korea
dDepartment of Physiology, The University of Texas Health Science Center at San Antonio, TX 78229-3900, USA
Evidence from many recent studies has linked uncontrolled inflammatory processes to aging and aging-related diseases. Decreased a nuclear receptor subfamily of transcription factors, peroxisome proliferator-activated receptors (PPARs) activity is closely associated with increased levels of inflammatory mediators during the aging process. The anti-inflammatory action of PPARs is substantiated by both in vitro and in vivo studies that signify the importance of PPARs as major players in the pathogenesis of many inflammatory diseases. In this review, we highlight the molecular mechanisms and roles of PPARα, γ in regulation of age-related inflammation. By understanding these current findings of PPARs, we open up the possibility of developing new therapeutic agents that modulate these nuclear receptors to control various inflammatory diseases such as atherosclerosis, vascular diseases, Alzheimer's disease, and cancer.
