近期發(fā)表在Trends in Endocrinology & Metabolism上的一篇文章指出,， 磷酸核糖轉(zhuǎn)移酶（nicotinamide phosphoribosyltransferase,，Nampt）在許多疾病包括2型糖尿病和癌癥具有重要的生理功能,。該文章詳細(xì)描述了Nampt作為煙酰胺轉(zhuǎn)化為煙酰胺單核苷酸過程的作用,，其中最重要的是產(chǎn)生 煙酰胺腺嘌呤二核苷酸磷酸（nicotinamide adenine dinucleotide，NAD）,，最近由于NAD的生化,、代謝、炎癥方面的研究深入,，Nampt可以調(diào)節(jié)消耗NAD酶如去乙?；窼irtuin的活性，影響應(yīng)急與代謝,，從而也引起了極大的興趣,，Nampt似乎應(yīng)該是具有免疫調(diào)節(jié)功能因子，在炎癥中發(fā)揮作用,。（生物谷Bioon.com）
生物谷推薦原始出處：
Trends in Endocrinology & Metabolism doi:10.1016/j.tem.2008.10.004
Nampt: linking NAD biology, metabolism and cancer
Antje Garten1, , Stefanie Petzold1, Antje K?rner1, Shin-ichiro Imai2, and Wieland Kiess1
1University of Leipzig, Hospital for Children and Adolescents, Research Laboratory, Oststr. 21-25, 04317 Leipzig, Germany
2Washington University School of Medicine, Department of Developmental Biology, Campus Box 8103, 660 South Euclid Avenue, St. Louis, MO 63110, USA
Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide to nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD) intermediate. Previously identified as a cytokine pre-B-cell colony-enhancing factor and controversially claimed as an insulin-mimetic hormone visfatin, Nampt has recently drawn much attention in several fields, including NAD biology, metabolism and inflammation. As a NAD biosynthetic enzyme, Nampt regulates the activity of NAD-consuming enzymes such as sirtuins and influences a variety of metabolic and stress responses. Nampt also plays an important part in regulating insulin secretion in pancreatic β-cells. Nampt seems to have another function as an immunomodulatory cytokine and, therefore, has a role in inflammation. This review summarizes these various functional aspects of Nampt and discusses its potential roles in diseases, including type 2 diabetes and cancer.
