美國一項(xiàng)最新研究發(fā)現(xiàn),，生物鐘與血糖調(diào)節(jié)密切相關(guān),。科研人員說,，這一發(fā)現(xiàn)將有助于更好地幫助調(diào)節(jié)人體血糖水平,。
美國加州大學(xué)醫(yī)學(xué)院的科研人員在新一期《國家科學(xué)院學(xué)報(bào)》上發(fā)表文章說，他們對實(shí)驗(yàn)鼠以及人類干細(xì)胞進(jìn)行試驗(yàn)時(shí)發(fā)現(xiàn),，在糖皮質(zhì)激素作用下,，有三個已知可以控制生物鐘的基因改變了自身的活性,。進(jìn)一步的研究發(fā)現(xiàn)，上述基因活性的改變直接與血糖水平調(diào)節(jié)相關(guān),。
參與這項(xiàng)研究的布賴恩·費(fèi)爾德曼博士指出,，他們的發(fā)現(xiàn)表明，生物體內(nèi)糖皮質(zhì)激素的日常變化,，與人體的生物鐘以及血糖水平密切相關(guān),。而一些含有糖皮質(zhì)激素的常用藥物，被較為廣泛地用于治療重度哮喘以及癌癥等,，這就導(dǎo)致患者可能因糖皮質(zhì)激素的作用而出現(xiàn)糖尿病這樣的副作用,。
費(fèi)爾德曼說，新發(fā)現(xiàn)將有助于醫(yī)生考慮如何配合人體生物鐘的節(jié)奏而正確使用相關(guān)藥物,。例如,，按照人體生物鐘的規(guī)律使用糖皮質(zhì)激素藥物，就能有效減小對血糖水平的干擾,；而對于那些已經(jīng)患有糖尿病的患者,，也可考慮運(yùn)用上述發(fā)現(xiàn)采用藥物來干預(yù)其體內(nèi)血糖水平的調(diào)節(jié),。(生物谷Bioon.com)
生物谷推薦原始出處：
PNAS October 5, 2009, doi: 10.1073/pnas.0909733106
Glucocorticoid regulation of the circadian clock modulates glucose homeostasis
Alex Y.-L. Soa,b, Teresita U. Bernala,b, Marlisa L. Pillsburyb, Keith R. Yamamotob,1 and Brian J. Feldmana,b,2
aDepartment of Pediatrics, University of California, 513 Parnassus Drive, San Francisco, CA 94143; and
bDepartment of Cellular and Molecular Pharmacology, University of California, 600 16th Street, S-222, San Francisco, CA 94158-2280
Circadian clock genes are regulated by glucocorticoids; however, whether this regulation is a direct or secondary effect and the physiological consequences of this regulation were unknown. Here, we identified glucocorticoid response elements (GREs) at multiple clock genes and showed that 3 were directly regulated by the glucocorticoid receptor. We determined that a GRE within the core clock gene Per2 was continuously occupied during rhythmic expression and essential for glucocorticoid regulation of that gene in vivo. We further demonstrated that mice with a genomic deletion spanning this GRE expressed elevated leptin levels and were protected from glucose intolerance and insulin resistance on glucocorticoid treatment but not from muscle wasting. We conclude that Per2 is an integral component of a particular glucocorticoid regulatory pathway and that glucocorticoid regulation of the peripheral clock is selectively required for some actions of glucocorticoids.
