日本產(chǎn)業(yè)技術(shù)綜合研究所近日發(fā)表公報(bào)說,，運(yùn)動可以刺激腦細(xì)胞合成一種名為Wnt3的蛋白質(zhì)，而這種蛋白質(zhì)能幫助大腦重返年輕,。
公報(bào)說，大腦內(nèi)掌管學(xué)習(xí)和記憶的海馬區(qū)內(nèi)有神經(jīng)干細(xì)胞。人成年后,，神經(jīng)干細(xì)胞仍然能夠不斷產(chǎn)生新的神經(jīng)細(xì)胞，保證海馬區(qū)的神經(jīng)細(xì)胞持續(xù)更新,。不過,，人步入老年后，海馬區(qū)神經(jīng)干細(xì)胞的細(xì)胞制造能力會逐漸減弱,，大腦的各項(xiàng)功能也隨之下降,。
產(chǎn)業(yè)技術(shù)綜合研究所的科研人員對比了年老實(shí)驗(yàn)鼠和年輕實(shí)驗(yàn)鼠在大腦海馬區(qū)的星形膠質(zhì)細(xì)胞的差異。星形膠質(zhì)細(xì)胞是腦內(nèi)神經(jīng)膠質(zhì)細(xì)胞的一種,。
科研人員發(fā)現(xiàn),，年老實(shí)驗(yàn)鼠的星形膠質(zhì)細(xì)胞生成蛋白質(zhì)Wnt3的能力明顯下降，只有年輕實(shí)驗(yàn)鼠的約三十分之一,?？蒲腥藛T猜測，Wnt3不足,，可能就是大腦神經(jīng)干細(xì)胞功能下降的原因,。
在進(jìn)一步的實(shí)驗(yàn)中，科研人員讓年老實(shí)驗(yàn)鼠短時(shí)間跑步,。鍛煉后,，實(shí)驗(yàn)鼠大腦產(chǎn)生Wnt3蛋白質(zhì)的能力有了大幅度的提高。隨之,，大腦神經(jīng)干細(xì)胞的活動也活躍起來,。科研人員說，如果堅(jiān)持鍛煉,，大腦就會重返年輕,。
此次成果的論文將刊登于即將出版的《美國實(shí)驗(yàn)生物學(xué)聯(lián)合會會志》（The FASEB Journal）上。(生物谷 Bioon.com)
doi:10.1096/fj.11-184697
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PMID:
Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis
Masahiro Okamoto, Koshiro Inoue, Hiroki Iwamura, Kazuyuki Terashima, Hideaki Soya, Makoto Asashima and Tomoko Kuwabara
Many persistent pain states (pain lasting for hours, days, or longer) are poorly treated because of the limitations of existing therapies. Analgesics such as nonsteroidal anti-inflammatory drugs and opioids often provide incomplete pain relief and prolonged use results in the development of severe side effects. Identification of the key mediators of various types of pain could improve such therapies. Here, we tested the hypothesis that hitherto unrecognized cytokines and chemokines might act as mediators in inflammatory pain. We used ultraviolet B (UVB) irradiation to induce persistent, abnormal sensitivity to pain in humans and rats. The expression of more than 90 different inflammatory mediators was measured in treated skin at the peak of UVB-induced hypersensitivity with custom-made
